Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation.
作者信息
Okumura Masayuki, Motegi Atsushi, Zenda Sadamoto, Nakamura Naoki, Hojo Hidehiro, Nakamura Masaki, Hirano Yasuhiro, Kageyama Shun-Ichiro, Arahira Satoko, Parshuram Raturi Vijay, Kuno Hirofumi, Hayashi Ryuichi, Tahara Makoto, Itoh Yoshiyuki, Naganawa Shinji, Akimoto Tetsuo
机构信息
Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
出版信息
Head Neck. 2020 Aug;42(8):1775-1782. doi: 10.1002/hed.26092. Epub 2020 Feb 7.
BACKGROUND
The purpose of this study was to evaluate accelerated fractionated radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic cancer (GC) without vocal cord fixation, especially in comparison with chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which included ENI.
METHODS
The medical charts of patients with T3N0GC without cord fixation received definitive radiotherapy between June 2005 and March 2018 were reviewed.
RESULTS
A total of 74 patients were analyzed. After a median follow-up time of 46 months (range, 12-141), 3-year local failure in AFRT/CRT/HFRT (n = 41/10/23) was 10%/20%/26%, 3-year regional failure 6%/0%/9%, 3-year progression-free survival 71%/69%/74%, and 3-year overall survival 77%/100%/87%. There were no significant differences among three groups in recurrence or survival. Grade 3 adverse events (AEs) were noted in 5/2/8 patients (12%/20%/35%) in AFRT/CRT/HFRT, respectively. There were no Grade 4/5 AEs.
CONCLUSIONS
AFRT without ENI is an effective and feasible treatment for T3N0GC without cord fixation.
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