乌干达坎帕拉一家城市门诊诊所中接受治疗的老年艾滋病毒感染者老年综合征患病率的性别差异
Sex Differences in the Prevalence of Geriatric Syndromes Among Older People Living with HIV Attending an Urban Outpatient Clinic in Kampala, Uganda.
作者信息
Mbabazi Phoebe, Banturaki Grace, Naikoba Suzan, Nasuuna Esther M, Manabe Yukari C, Greene Meredith, Castelnuovo Barbara
机构信息
Research Department, Infectious Disease Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Division of Infectious Diseases, Department of Medicine, John Hopkins University, Baltimore, MD, USA.
出版信息
HIV AIDS (Auckl). 2024 Nov 26;16:455-465. doi: 10.2147/HIV.S489598. eCollection 2024.
BACKGROUND
Older people living with HIV (PLHIV) are at high risk of developing geriatric syndromes. Data on geriatric syndromes among older PLHIV in sub-Saharan Africa are scarce. We examined sex differences in the prevalence and correlates of geriatric syndromes among PLHIV aged ≥60 years on antiretroviral therapy in Kampala, Uganda.
METHODS
This cross-sectional study analyzed data obtained during the enrollment of older PLHIV into a prospective observational cohort in Kampala. We used the Poisson regression model to explore the association between the number of geriatric syndromes and non-communicable diseases (NCDs), sociodemographic factors, and HIV-related factors.
RESULTS
We included 500 participants (48.8% women) with a median age of 64 years (interquartile range, IQR: 62.68). Almost all (94.4%) participants had at least one geriatric syndrome. More women were frail (13.1% vs 5.1%, P-value = 0.01) and had lower physical performance measured using the Short Physical Performance Battery (43.3% vs 26.6%, P-value < 0.01). Similarly, more women had cognitive impairment (83.2% vs 62.9%, P-value < 0.01) and reported falling (48.8% vs 34.0%, P-value < 0.01). Women (adjusted mean ratio, AMR 1.17, 95% CI 1.05-1.30, P-value < 0.01), older age (AMR 1.11, 95% CI 1.07-1.16, P-value < 0.01), no formal education (AMR 1.39, 95% CI 1.06-1.82, P-value = 0.01), underweight (AMR 1.49, 95% CI 1.26-1.76, P-value < 0.01), World Health Organization (WHO) stage 3 or 4 (AMR 1.11, 95% CI 0.01-1.22, P-value = 0.04) and having two or more NCDs (AMR 1.11, 95% CI 1.00-1.23, P-value = 0.04) were associated with a higher number of geriatric syndromes.
CONCLUSION
The prevalence of geriatric syndromes was high among older PLHIV and was more common in women. There is a need to incorporate the screening and management of geriatric syndromes into the care of older PLHIV in sub-Saharan Africa, with a particular focus on women.
背景
感染艾滋病毒的老年人（PLHIV）患老年综合征的风险很高。撒哈拉以南非洲地区老年PLHIV中关于老年综合征的数据很少。我们研究了乌干达坎帕拉接受抗逆转录病毒治疗的60岁及以上PLHIV中，老年综合征患病率及相关因素的性别差异。
方法
这项横断面研究分析了在坎帕拉将老年PLHIV纳入前瞻性观察队列时获得的数据。我们使用泊松回归模型来探讨老年综合征数量与非传染性疾病（NCDs）、社会人口学因素和艾滋病毒相关因素之间的关联。
结果
我们纳入了500名参与者（48.8%为女性），中位年龄为64岁（四分位间距，IQR：62 - 68）。几乎所有（94.4%）参与者至少有一种老年综合征。更多女性身体虚弱（13.1%对5.1%，P值 = 0.01），并且使用简短身体功能量表测量的身体表现较低（43.3%对26.6%，P值 < 0.01）。同样，更多女性有认知障碍（83.2%对62.9%，P值 < 0.01）且报告有跌倒情况（48.8%对34.0%，P值 < 0.01）。女性（调整后平均比率，AMR 1.17，95%置信区间1.05 - 1.30，P值 < 0.01）、年龄较大（AMR
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