Sandberg A A, Morgan S S, Morgan R, Boros L
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Cancer Genet Cytogenet. 1988 Nov;36(1):31-4. doi: 10.1016/0165-4608(88)90072-6.
We present a case of B-cell acute lymphoblastic leukemia (ALL) in whose leukemic cells trisomy 5 (+5) was the only cytogenetic anomaly observed. This is the first report of +5 as the sole cytogenetic abnormality in ALL; two cases (one questionable) of acute nonlymphocytic leukemia with such a change have been reported. The findings are presented in relation to other cases with +5 as part of a more complicated cytogenetic picture in hematologic disorders.
我们报告了一例B细胞急性淋巴细胞白血病（ALL），其白血病细胞中5号染色体三体（+5）是观察到的唯一细胞遗传学异常。这是ALL中+5作为唯一细胞遗传学异常的首例报告；已有两例（其中一例存疑）急性非淋巴细胞白血病出现这种变化的报告。本文结合血液系统疾病中+5作为更复杂细胞遗传学图谱一部分的其他病例呈现了这些发现。
