高盐饮食诱导的C57BL/6小鼠胃炎与微生物群落失调有关，且荞麦饮食可缓解该症状。
High-Salt Diet-Induced Gastritis in C57BL/6 Mice is Associated with Microbial Dysbiosis and Alleviated by a Buckwheat Diet.
作者信息
Li Ya, Li Wen, Wang Xiao, Ding Chao, Liu Junze, Li Yan, Li Wenjuan, Sun Yundong
机构信息
Department of Microbiology, Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunology of Shandong Province, School of Basic Medicine, Shandong University, Jinan, 250012, China.
Department of Pathology, School of Basic Medicine, Shandong University, Jinan, 250012, China.
出版信息
Mol Nutr Food Res. 2020 Apr;64(8):e1900965. doi: 10.1002/mnfr.201900965. Epub 2020 Feb 16.
SCOPE
A high-salt diet is a cause of gastritis, but the associated mechanism remains unclear. Recent studies have shown that gastric flora is associated with a variety of stomach diseases, but it is not known whether gastric flora is involved in gastritis induced by a high-salt diet.
METHODS AND RESULTS
Gastritis is successfully induced in C57BL/6 mice fed a high-salt diet (salt: 5% NaCl) for four weeks. Through 16S rRNA gene sequencing, the composition of the stomach microbiota of mice fed normal and high-salt diets are compared, the results of which show that the high-salt diet induces significant changes in the gastric flora. Phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) is used to predict the function of the microbiota in the stomach of mice, and the results indicate that a high-salt diet leads to a decrease in the ability of the gastric microbiota to metabolize polysaccharides and vitamins. A buckwheat diet is used to treat gastritis. The results show gastritis induced by the high-salt diet is significantly alleviated, and the dysbiosis in the stomach also improved.
CONCLUSION
Buckwheat diet may be one of the ways to prevent and treat gastritis caused by a high-salt diet.
范围
高盐饮食是胃炎的一个病因，但其相关机制仍不清楚。最近的研究表明，胃微生物群与多种胃部疾病有关，但尚不清楚胃微生物群是否参与高盐饮食诱发的胃炎。
方法与结果
给C57BL/6小鼠喂食高盐饮食（盐：5%氯化钠）四周，成功诱发胃炎。通过16S rRNA基因测序，比较正常饮食和高盐饮食小鼠的胃微生物群组成，结果表明高盐饮食会引起胃微生物群的显著变化。利用未观察状态重建的群落系统发育研究（PICRUSt）预测小鼠胃中微生物群的功能，结果表明高盐饮食会导致胃微生物群代谢多糖和维生素的能力下降。用荞麦饮食治疗胃炎。结果显示，高盐饮食诱发的胃炎明显减轻，胃内的生态失调也得到改善。
结论
荞麦饮食可能是预防和治疗高盐饮食所致胃炎的方法之一。
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