The Postgraduate Program in Health Sciences, School of Social Sciences and Health, Nutrition Course, Pontifical Catholic University of Goiás, Goiânia, 74605-020 Goiás, Brazil.
The Postgraduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, 74605-220 Goiás, Brazil.
Nutrients. 2020 Feb 4;12(2):403. doi: 10.3390/nu12020403.
Dietary interventions can stabilize and/or reverse bone mass loss. However, there are no reports on its effects on bone mineral density (BMD) in severely obese people, despite the vulnerability of this group to bone loss. We examine the effect of extra virgin olive oil supplementation and the traditional Brazilian diet (DieTBra) on BMD and levels of calcium, vitamin D, and parathyroid hormone (PTH) in severely obese adults. A randomized controlled trial followed-up with severely obese adults ( = 111, with mean body mass index 43.6 kg/m ± 4.5 kg/m) for 12 weeks. Study participants received either olive oil (52 mL/day), DieTBra, or olive oil + DieTBra (52 mL/day + DieTBra). BMD was assessed by total spine and hip dual-energy X-ray absorptiometry. After interventions, BMD means for total spine ( = 0.016) and total hip ( = 0.029) were higher in the DieTBra group than in the olive oil + DieTBra group. Final mean calcium levels were higher in the olive oil group compared to the olive oil + DieTBra group ( = 0.026). Findings suggest that DieTBra and extra virgin olive oil have positive effects on bone health in severely obese adults. The major study was registered at ClinicalTrials.gov (NCT02463435).
饮食干预可以稳定和/或逆转骨量流失。然而，尽管肥胖人群容易出现骨丢失，但目前尚无关于其对严重肥胖者骨密度（BMD）影响的报道。我们研究了特级初榨橄榄油补充剂和传统巴西饮食（DieTBra）对严重肥胖成年人 BMD 以及钙、维生素 D 和甲状旁腺激素（PTH）水平的影响。一项随机对照试验对 111 名严重肥胖成年人（平均体重指数为 43.6 kg/m ± 4.5 kg/m）进行了为期 12 周的随访。研究参与者接受橄榄油（52 mL/天）、DieTBra 或橄榄油+DieTBra（52 mL/天+DieTBra）治疗。通过全脊柱和髋关节双能 X 射线吸收法评估 BMD。干预后，DieTBra 组全脊柱（ = 0.016）和全髋关节（ = 0.029）的 BMD 平均值高于橄榄油+DieTBra 组。橄榄油组的最终平均钙水平高于橄榄油+DieTBra 组（ = 0.026）。研究结果表明，DieTBra 和特级初榨橄榄油对严重肥胖成年人的骨骼健康有积极影响。主要研究在 ClinicalTrials.gov（NCT02463435）注册。
