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老年男性前列腺癌行机器人辅助根治性前列腺切除术后的功能和围手术期结果。

Functional and perioperative outcomes in elderly men after robotic-assisted radical prostatectomy for prostate cancer.

机构信息

Division of Urology, Department of Surgery, Centre hospitalier de l'université de Montréal (CHUM), Montreal, QC, Canada.

Faculty of Medicine, McGill University, Montreal, QC, Canada.

出版信息

World J Urol. 2020 Nov;38(11):2791-2798. doi: 10.1007/s00345-020-03096-0. Epub 2020 Feb 7.

Abstract

PURPOSE

We aimed to compare postoperative functional outcomes following robotic-assisted radical prostatectomy (RARP) in elderly men with localized prostate cancer.

METHODS

A retrospective review of a prospectively maintained database of men who underwent RARP between January 2007 and November 2018 was performed. Patients over 65 years of age were selected (N = 302) and then stratified by age group: 66-69 years old (N = 214) and ≥ 70 years old (N = 88). Full continence was defined as strict 0-pad per day usage. Preoperative potency included those with a Sexual Health Inventory for Men score ≥ 17. Preoperative and postoperative functional outcomes were assessed. Kaplan-Meier analysis was used to estimate time to recovery of continence in both groups.

RESULTS

Both groups had comparable preoperative parameters. Continence rates at 1, 3, 6, 9, 12, 18 and 24 months in the 66-69-year-old group were 6%, 34%, 61%, 70%, 74%, 80% and 87%, respectively. Comparatively in the ≥ 70-year-old group, continence rates were significantly lower at all time points (3%, 22%, 50%, 56%, 66%, 69% and 75%, respectively). Men in the 66-69-year-old group were significantly more likely to be continent after RARP when compared to patients 70 years of age and above [(Hazards ratio (HR) 0.73; 95%confidence interval 0.54-0.97, (p = 0.035)].

CONCLUSION

Our results suggest that RARP is feasible in elderly patients. Nevertheless, elderly patients in the ≥ 70-year-old group had significantly inferior postoperative continence rates compared to patients aged 66-69 years. Such information is valuable when counselling men during preoperative RARP planning to ensure that they have realistic postoperative expectations.

摘要

目的

我们旨在比较接受机器人辅助根治性前列腺切除术(RARP)的老年局限性前列腺癌患者的术后功能结局。

方法

对 2007 年 1 月至 2018 年 11 月期间接受 RARP 的男性患者前瞻性维护数据库进行回顾性分析。选择年龄超过 65 岁的患者(N=302),然后按年龄组分层:66-69 岁(N=214)和≥70 岁(N=88)。完全控尿定义为每天严格使用 0 个尿垫。术前勃起功能包括那些男性健康问卷调查表(MEN)评分≥17 的患者。评估术前和术后的功能结果。Kaplan-Meier 分析用于估计两组患者恢复控尿的时间。

结果

两组患者术前参数相似。66-69 岁组术后 1、3、6、9、12、18 和 24 个月的控尿率分别为 6%、34%、61%、70%、74%、80%和 87%。相比之下,≥70 岁组在所有时间点的控尿率均显著较低(分别为 3%、22%、50%、56%、66%、69%和 75%)。与 70 岁以上的患者相比,66-69 岁组患者在接受 RARP 后更有可能控制尿失禁[危险比(HR)0.73;95%置信区间 0.54-0.97,(p=0.035)]。

结论

我们的结果表明,RARP 对老年患者是可行的。然而,≥70 岁的老年患者术后控尿率明显低于 66-69 岁的患者。在进行术前 RARP 规划时向男性提供咨询时,这些信息很有价值,以确保他们对术后结果有现实的期望。

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