Alhazmi Fahad H, Abdulaal Osama M, Qurashi Abdulaziz A, Aloufi Khalid M, Sluming Vanessa
Department of Diagnostic Radiology Technology, Faculty of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
Institute of Translational Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
Insights Imaging. 2020 Feb 7;11(1):17. doi: 10.1186/s13244-019-0821-8.
Brain morphometry is an important assessment technique to assess certain morphological brain features of various brain regions, which can be quantified in vivo by using high-resolution structural magnetic resonance (MR) imaging. This study aims to investigate the effect of different types of pulse sequence on regional corpus callosum (CC) morphometry analysis.
Twenty-one healthy volunteers were scanned twice on the same 3T MRI scanner (Magnetom Trio, Siemens, Erlangen, Germany) equipped with an 8-channel head coil. Two different MR pulse sequences were applied to acquire high-resolution 3D T1-weighted images: magnetization-prepared rapid gradient-echo (MP-RAGE) and modified driven equilibrium Fourier transform (MDEFT) pulse sequence. Image quality measurements such as SNR, contrast-to-noise ratio, and relative contrast were calculated for each pulse sequence images independently. The values of corpus callosum volume were calculated based on the vertex of reconstructed surfaces. The paired dependent t test was applied to compare the means of two matched groups.
Three sub-regional CC, namely anterior, mid-anterior, and posterior, resulted in an estimated volume difference between MDEFT and MP-RAGE pulse sequences. Central and mid-posterior sub-regional CC volume resulted in not significant difference between the two named pulse sequences.
The findings of this study demonstrate that combining data from different pulse sequences in a multisite study could make some variations in the results.
脑形态测量是评估不同脑区某些脑形态特征的重要评估技术，可通过高分辨率结构磁共振成像在体内进行量化。本研究旨在探讨不同类型脉冲序列对区域胼胝体（CC）形态测量分析的影响。
21名健康志愿者在配备8通道头部线圈的同一台3T磁共振成像扫描仪（德国西门子公司的Magnetom Trio）上进行了两次扫描。应用两种不同的磁共振脉冲序列采集高分辨率3D T1加权图像：磁化准备快速梯度回波（MP-RAGE）和改良驱动平衡傅里叶变换（MDEFT）脉冲序列。分别独立计算每个脉冲序列图像的图像质量测量值，如信噪比、对比噪声比和相对对比度。基于重建表面的顶点计算胼胝体体积值。应用配对t检验比较两个匹配组的均值。
三个亚区域CC，即前部、前中部和后部，在MDEFT和MP-RAGE脉冲序列之间产生了估计的体积差异。中部和后中部亚区域CC体积在这两种脉冲序列之间没有显著差异。
本研究结果表明，在多中心研究中结合来自不同脉冲序列的数据可能会使结果产生一些差异。
