Jia Xue-Xia, Wang Hui, Liu Ying, Meng De-Mei, Fan Zhen-Chuan
State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China.
State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China.
Microb Pathog. 2020 Feb 6;142:104045. doi: 10.1016/j.micpath.2020.104045.
Peste des petits ruminants (PPR) is a highly contagious and fatal disease of small ruminants, particularly sheep and goats. This disease leads to high morbidity and mortality of small ruminants, thus resulting in devastating economic loss to the livestock industry globally. The severe disease impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (OIE) to develop a global strategy for the control and eradication of PPR by 2030. Over the past decades, the control of PPR is mainly achieved through vaccinating the animals with live-attenuated vaccines, e.g., rinderpest vaccines. As a closely related disease to PPR of large ruminants, rinderpest was eradicated in 2011 and its vaccines subsequently got banned in order to keep rinderpest-free zones. Consequently, it is desirable to develop homologous PPR vaccines to control the disease. The present review summarizes the objectives of PPR control and eradication by focusing on the homologous PPR vaccines.
小反刍兽疫（PPR）是一种小反刍动物的高度传染性致命疾病，尤其是绵羊和山羊。这种疾病导致小反刍动物的高发病率和死亡率，从而给全球畜牧业造成毁灭性的经济损失。严重的疾病影响促使联合国粮食及农业组织（FAO）和世界动物卫生组织（OIE）制定了到2030年控制和根除小反刍兽疫的全球战略。在过去几十年中，小反刍兽疫的控制主要通过用减毒活疫苗（如牛瘟疫苗）给动物接种来实现。作为大型反刍动物中与小反刍兽疫密切相关的疾病，牛瘟于2011年被根除，其疫苗随后被禁止使用，以保持无牛瘟区。因此，开发同源小反刍兽疫疫苗来控制该疾病是很有必要的。本综述通过聚焦同源小反刍兽疫疫苗总结了控制和根除小反刍兽疫的目标。
