School of Pharmacy and Biomedical Science, Curtin University, Bentley, 6102, Australia; Curtin Health Innovation Research Institute, Bentley, 6102, Australia.
School of Pharmacy and Biomedical Science, Curtin University, Bentley, 6102, Australia; Curtin Health Innovation Research Institute, Bentley, 6102, Australia; Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, India.
Exp Cell Res. 2020 Apr 15;389(2):111891. doi: 10.1016/j.yexcr.2020.111891. Epub 2020 Feb 5.
Pigment epithelium-derived factor (PEDF) is an endogenous human glycoprotein first identified as a neurotrophic factor in retinal pigmented epithelium cells. PEDF has since been shown to play a central role in mediating cellular protection against oxidative stress, by promoting cell survival, reducing inflammation, and inhibiting pathological angiogenesis in a range of cell types and tissues. PEDF is a well-established neurotrophic factor which supports neurogenesis and provides neuroprotection in response to cellular stress, with numerous studies demonstrating the ability of PEDF to promote neuronal survival and growth following injury. PEDF is an essential component of the stem cell microenvironment and bone extracellular matrix, where it regulates the differentiation of osteoblast precursor cells to promote normal bone development. Accumulating evidence indicates that PEDF maintains stem cell populations and promotes neuronal growth and bone formation by directing cell fate and regulating cell cycle progression. The ability of PEDF to promote neurogenesis, osteogenesis, and stemness indicates therapeutic potential in diseases characterised by tissue degeneration. In this review, we provide a current summary of the role of PEDF in regulating cellular survival and differentiation in bone, the central nervous system, and other stem cell niches, and highlight the emerging potential of PEDF as a regenerative therapeutic agent.
色素上皮衍生因子（PEDF）是一种内源性人糖蛋白，最初在视网膜色素上皮细胞中被鉴定为一种神经营养因子。此后，PEDF 已被证明在介导细胞对氧化应激的保护中发挥核心作用，通过促进细胞存活、减少炎症和抑制多种细胞类型和组织中的病理性血管生成。PEDF 是一种成熟的神经营养因子，可支持神经发生并在细胞应激时提供神经保护，大量研究表明 PEDF 能够促进损伤后神经元的存活和生长。PEDF 是干细胞微环境和骨细胞外基质的重要组成部分，在其中它调节成骨细胞前体细胞的分化，以促进正常骨发育。越来越多的证据表明，PEDF 通过指导细胞命运和调节细胞周期进程来维持干细胞群体并促进神经元生长和骨形成。PEDF 促进神经发生、成骨和干细胞特性的能力表明其在以组织退化为特征的疾病中具有治疗潜力。在这篇综述中，我们提供了 PEDF 在调节骨、中枢神经系统和其他干细胞龛中细胞存活和分化的作用的最新总结，并强调了 PEDF 作为一种再生治疗剂的新兴潜力。
