Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Cell and Molecular Biology, Faculty of Basic Science, University of Maragheh, Maragheh, Iran.
Department of Cell and Molecular Biology, Faculty of Basic Science, University of Maragheh, Maragheh, Iran.
Gene. 2020 May 15;738:144453. doi: 10.1016/j.gene.2020.144453. Epub 2020 Feb 5.
Breast cancer (BC) is the most common cancer among women that is responsible for the most of the cancer-related death in worldwide. Drug resistance is remaining as a significant clinical obstacle to treat BC patients effectively. Therefore, to help overcome this problem, it is necessary to understand the mechanisms of drug resistance. microRNAs classify as highly conserved non-coding RNAs (~22 nucleotides) and interact with mRNAs-coding genes for direct post-transcriptional repression. It has been reported that miR-21 is overexpressed and also acts as oncomiR in many human malignancies by targeting of several tumor suppressor genes-associated with apoptosis, proliferation and metastasis. Specifically, it has been reported that miR-21 is responsible for the drug resistance and its overexpression is related to the development of Multi Drug Resistance (MDR) in breast cancer. In this review, we discussed about the role of miR-21 on the drug resistance of breast cancer.
乳腺癌（BC）是女性中最常见的癌症，也是全球癌症相关死亡的主要原因。耐药性仍然是有效治疗 BC 患者的重大临床障碍。因此，为了帮助克服这个问题，有必要了解耐药性的机制。 microRNAs 被归类为高度保守的非编码 RNA（~22 个核苷酸），并与编码基因的 mRNAs 相互作用，以进行直接的转录后抑制。据报道，miR-21 在许多人类恶性肿瘤中过表达，并通过靶向与凋亡、增殖和转移相关的几个肿瘤抑制基因发挥致癌作用。具体来说，据报道，miR-21 负责乳腺癌的耐药性，其过表达与乳腺癌多药耐药（MDR）的发展有关。在这篇综述中，我们讨论了 miR-21 在乳腺癌耐药性中的作用。
