Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
Trends Immunol. 2020 Mar;41(3):190-199. doi: 10.1016/j.it.2020.01.002. Epub 2020 Feb 5.
For decades, insect immunology has contributed groundbreaking discoveries on the intricacies of innate immunity. These discoveries have profoundly impacted our understanding of innate immunology in mammalian systems and improved human therapeutic interventions, from the composition of vaccines to cell-based immune therapies. Current knowledge of insect immunity mainly encompasses detailed molecular mechanisms and systemic responses to pathogen infection. However, the organs and specific cell populations involved in immune responses remain elusive. Here, we highlight the need for a better understanding of insect immune responses at the level of organs and cell populations. Not only will it improve our current understanding of tissue- or cell-specific immune processes across species, but it will also pave the way for spatial modeling of within-host infection dynamics.
几十年来，昆虫免疫学在先天免疫的复杂性方面做出了开创性的发现。这些发现深刻地影响了我们对哺乳动物系统先天免疫学的理解，并改善了人类的治疗干预措施，从疫苗的组成到基于细胞的免疫疗法。目前对昆虫免疫的认识主要包括对病原体感染的详细分子机制和系统反应。然而，参与免疫反应的器官和特定细胞群体仍然难以捉摸。在这里，我们强调需要更好地了解器官和细胞群体水平的昆虫免疫反应。这不仅将提高我们对跨物种组织或细胞特异性免疫过程的现有理解，还将为宿主内感染动力学的空间建模铺平道路。
