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细菌对宫颈癌的抗癌作用:分子方面及治疗意义。

Anticancer effect of bacteria on cervical cancer: Molecular aspects and therapeutic implications.

机构信息

Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Research Center of Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Life Sci. 2020 Apr 1;246:117413. doi: 10.1016/j.lfs.2020.117413. Epub 2020 Feb 6.

Abstract

Cervical cancer is the second common cancer and the third leading cause of cancer deaths among women in less developed countries. It has been indicated that changes in vaginal microbiome play an important role in the occurrence and development of cervical cancer. However, studies have shown that probiotics play an effective role in fighting cancer by affecting pathogenic bacteria, inducing cancer cells apoptosis, and other anticancer activities. Therefore, the purpose of the present study is reviewing the anticancer effect of cervicovaginal bacteria and their potential for cervical cancer treatment.

摘要

宫颈癌是发展中国家女性中第二大常见癌症和第三大癌症死亡原因。有研究表明,阴道微生物组的变化在宫颈癌的发生和发展中起着重要作用。然而,研究表明,益生菌通过影响致病菌、诱导癌细胞凋亡等抗癌作用,在抗癌方面发挥着有效的作用。因此,本研究旨在综述宫颈阴道细菌的抗癌作用及其在宫颈癌治疗中的潜力。

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