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是 X 染色体失活所必需的最小启动子（P1）。

The minimal promoter (P1) of is non-essential for X chromosome inactivation.

机构信息

Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

出版信息

RNA Biol. 2020 May;17(5):623-629. doi: 10.1080/15476286.2020.1725725. Epub 2020 Feb 9.

DOI:10.1080/15476286.2020.1725725
PMID:32036747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7237162/
Abstract

The previous report shows the minimal promoter (P1) contributes to the RNA activation in cells, while the role of the P1 has not yet been investigated in animal individuals. Here, female P1 knockout rabbits ( P1) were generated for the studies. The results showed that there is no significant difference in transmission ratio, and X-linked genes expression, and RNA localization between the female wild type (WT) and P1 rabbits, suggesting that P1 is non-essential for expression and XCI in rabbits. Our study has explored the function of P1 in animal level for the first time, and the results provide new ideas for future studies of XCI mechanisms.

摘要

先前的报告表明，微启动子（P1）有助于细胞中的 RNA 激活，而 P1 在动物个体中的作用尚未得到研究。在这里，我们生成了雌性 P1 敲除兔（P1）以进行研究。结果表明，雌性野生型（WT）和 P1 兔之间的传递率、X 连锁基因表达和 RNA 定位没有显著差异，这表明 P1 对于兔的表达和 XCI 并非必需。我们的研究首次在动物水平上探索了 P1 的功能，为未来研究 XCI 机制提供了新的思路。

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引用本文的文献

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Cell Mol Life Sci. 2024 Mar 29;81(1):156. doi: 10.1007/s00018-024-05151-0.
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Genome-edited rabbits: Unleashing the potential of a promising experimental animal model across diverse diseases.基因组编辑兔：在多种疾病中释放有前途的实验动物模型的潜力。
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本文引用的文献

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Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System.从贴壁单层培养系统中分离、鉴定和评估人皮肤来源前体细胞的安全性
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Jpx RNA activates Xist by evicting CTCF.Jpx RNA 通过驱逐 CTCF 来激活 Xist。
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Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development.真兽类哺乳动物在发育过程中使用多种策略来启动 X 染色体失活。
Nature. 2011 Apr 21;472(7343):370-4. doi: 10.1038/nature09872. Epub 2011 Apr 6.
10
Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.Ftx 是一种非编码 RNA，可影响 X 失活中心区域内 Xist 的表达和染色质结构。
Hum Mol Genet. 2011 Feb 15;20(4):705-18. doi: 10.1093/hmg/ddq516. Epub 2010 Nov 30.