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原发性皮肤印戒细胞（组织细胞样）癌的罕见病例。

Unusual case of primary cutaneous signet-ring cell (histocytoid) carcinoma.

作者信息

Sayan Anna, Mitchell Oliver, Taibjee Saleem, Ilankovan Velupillai

机构信息

Poole Hospital NHS Foundation Trust.

University Hospital Southampton NHS Foundation Trust.

出版信息

Br J Oral Maxillofac Surg. 2020 May;58(4):475-477. doi: 10.1016/j.bjoms.2020.01.023. Epub 2020 Feb 7.

DOI:10.1016/j.bjoms.2020.01.023
PMID:32037138
Abstract

Signet-ring cell (histocytoid) carcinoma is a rare and aggressive skin neoplasm that most commonly affects elderly men. It typically originates from the upper or lower eyelid, with bilateral involvement only in rare cases, and results in a diffuse and infiltrative appearance clinically, radiologically, and histologically (the "monocle" sign). It is essential to carry out a full investigation to rule out metastasis from an internal origin.

摘要

印戒细胞（组织细胞样）癌是一种罕见且侵袭性强的皮肤肿瘤，最常累及老年男性。它通常起源于上睑或下睑，仅在极少数情况下双侧受累，在临床、放射学和组织学上均表现为弥漫性浸润外观（“单眼镜”征）。进行全面检查以排除源自体内其他部位的转移至关重要。

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引用本文的文献

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Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.具有大汗腺和小汗腺分化的皮肤附件肿瘤的当前诊断和治疗选择。
Int J Mol Sci. 2021 May 11;22(10):5077. doi: 10.3390/ijms22105077.
2
Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents.眼睑原发性印戒细胞/组织细胞样癌： 和其他临床可操作突变的体细胞突变提示早期使用靶向药物。
Curr Oncol. 2021 Feb 16;28(1):918-927. doi: 10.3390/curroncol28010090.