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多囊卵巢综合征女性患者中代谢综合征的预测因素

Predictors of Metabolic Syndrome among Polycystic Ovary Syndrome Sisters.

作者信息

Kulshreshtha Bindu, Sharma Neera, Pant Shubhi, Prasad Akhila, Chitkara Anubhuti, Pahuja Bhawna, Pahuja Isha

机构信息

Department of Endocrinology, PGIMER, Dr. RML Hospital, New Delhi, India.

Department of Biochemistry, PGIMER, Dr. RML Hospital, New Delhi, India.

出版信息

J Hum Reprod Sci. 2019 Oct-Dec;12(4):334-340. doi: 10.4103/jhrs.JHRS_172_18. Epub 2019 Dec 17.

DOI:10.4103/jhrs.JHRS_172_18
PMID:32038085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6937762/
Abstract

AIMS

Metabolic syndrome among PCOS sisters may vary depending on the phenotype. The aim of the present study was to analyze the prevalence of metabolic syndrome among different phenotypes of PCOS sisters.

DESIGN

Case control study.

MATERIALS AND METHODS

Two hundred sisters of PCOS patients and 99 age matched healthy controls underwent history, clinical examination, biochemical parameters for metabolic syndrome and hormonal assessment.

RESULTS

Of 200 sisters, 85 were unaffected (UA group), 21 sisters had hyperandrogenemia (HA group), and 94 sisters had irregular periods or hyperandrogenemia. We observed that the frequency of metabolic syndrome among PCOS sisters was comparable to age and weight matched controls (30% vs 27%). The prevalence of metabolic syndrome was higher in HA and AFFECTED sisters (around 30% in both) compared to UA sisters (20%). The presence of metabolic syndrome was significantly associated with age, BMI, HOMA-IR and free testosterone. After correction for age and BMI, metabolic syndrome was significantly associated with HOMA-IR ( - 0.05) and free testosterone ( - 0.03).

CONCLUSION

Based on above findings, we conclude that affected sisters and those with higher age, BMI and hyperandrogenemia have a high risk of metabolic syndrome compared to unaffected sisters.

摘要

目的

多囊卵巢综合征（PCOS）女性患者的代谢综合征可能因表型而异。本研究的目的是分析不同表型PCOS女性患者中代谢综合征的患病率。

设计

病例对照研究。

材料与方法

200名PCOS患者的姐妹和99名年龄匹配的健康对照者接受了病史、临床检查、代谢综合征的生化参数检测及激素评估。

结果

在200名姐妹中，85名未受影响（未受影响组），21名姐妹有高雄激素血症（高雄激素血症组），94名姐妹有月经不规律或高雄激素血症。我们观察到，PCOS姐妹中代谢综合征的发生率与年龄和体重匹配的对照组相当（30%对27%）。与未受影响的姐妹（20%）相比，高雄激素血症组和受影响的姐妹中代谢综合征的患病率更高（两者均约为30%）。代谢综合征的存在与年龄、体重指数（BMI）、胰岛素抵抗稳态模型评估（HOMA-IR）和游离睾酮显著相关。校正年龄和BMI后，代谢综合征与HOMA-IR（-0.05）和游离睾酮（-0.03）显著相关。

结论

基于上述发现，我们得出结论，与未受影响的姐妹相比？受影响的姐妹以及年龄较大、BMI较高和高雄激素血症的姐妹患代谢综合征的风险较高。 （注：原文中“compared to unaffected sisters”前的“？”为原文错误，未做翻译调整）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c2/6937762/748047094f3c/JHRS-12-334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c2/6937762/f40f97fd3875/JHRS-12-334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c2/6937762/748047094f3c/JHRS-12-334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c2/6937762/f40f97fd3875/JHRS-12-334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c2/6937762/748047094f3c/JHRS-12-334-g002.jpg

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Indian J Endocrinol Metab. 2014 May;18(3):364-9. doi: 10.4103/2230-8210.131186.
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Determinants of dyslipidaemia in probands with polycystic ovary syndrome and their sisters.
多囊卵巢综合征患者及其姐妹血脂异常的决定因素。
Clin Endocrinol (Oxf). 2011 Jun;74(6):714-9. doi: 10.1111/j.1365-2265.2011.03983.x.
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Metab Syndr Relat Disord. 2009 Dec;7(6):497-514. doi: 10.1089/met.2009.0024.
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The metabolic syndrome and dyslipidemia among Asian Indians: a population with high rates of diabetes and premature coronary artery disease.亚洲印度人群中的代谢综合征和血脂异常：糖尿病和早发性冠状动脉疾病高发人群。
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