Shabir Iram, Ganie Mohd Ashraf, Zargar Mohd Afzal, Bhat Dilafroz, Mir Mohd Muzzafar, Jan Aleem, Shah Zaffar Amin, Jan Vicar, Rasool Riyaz, Naqati Andleeb
PhD Scholar, All India Institute of Medical Sciences, New Delhi, India.
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Endocrinol Metab. 2014 May;18(3):364-9. doi: 10.4103/2230-8210.131186.
Polycystic ovary syndrome (PCOS) is the most complex and common endocrine disorder of women in reproductive years. In addition to irregular menstrual cycles, chronic anovulation and hyperandrogenism, it has many metabolic manifestations such as obesity, hyperlipidemia, hyperinsulinemia, insulin resistance, dysglycemia, increased risk of cardiovascular disease or possibly endometrial cancer. Familial clustering of PCOS in consistence with the genetic susceptibility has been described.
The present study assessed the clinical, biochemical and hormonal parameters including prevalence of metabolic syndrome by two different criteria in the first- degree relatives of patients with PCOS.
The average age of 37 index patients was 23 ± 3.6 years, with the mean age of menarche as 13.3 ± 1.2 years. The mean age and age of menarche in mothers (n = 22) was 48.8 ± 5.1 and 13 ± 1.3 years, respectively, whereas as it was 23.5 ± 4.7 and 13.3 ± 1.2 years in sisters (n = 22), respectively. Metabolic syndrome (MS) defined by International Diabetes Federation (IDF) criteria was present in 10 index patients, 1 brother, 4 sisters, 17 mothers and 15 fathers while as by Adult Treatment Panel III (ATP III) it was in 8 index patients, 5 sisters, 16 mothers and 11 fathers.
The presence of MS or related metabolic derangements is high in the family members of women with PCOS.
多囊卵巢综合征（PCOS）是育龄期女性最复杂且常见的内分泌紊乱疾病。除月经周期不规律、慢性无排卵和高雄激素血症外，它还有许多代谢表现，如肥胖、高脂血症、高胰岛素血症、胰岛素抵抗、血糖异常、心血管疾病风险增加或可能患子宫内膜癌。PCOS的家族聚集现象与遗传易感性相符。
本研究通过两种不同标准评估了PCOS患者一级亲属的临床、生化和激素参数，包括代谢综合征的患病率。
37例索引患者的平均年龄为23±3.6岁，初潮平均年龄为13.3±1.2岁。母亲（n = 22）的平均年龄和初潮年龄分别为48.8±5.1岁和13±1.3岁，而姐妹（n = 22）的平均年龄和初潮年龄分别为23.5±4.7岁和13.3±1.2岁。按照国际糖尿病联盟（IDF）标准定义的代谢综合征（MS）在10例索引患者、1名兄弟、4名姐妹、17名母亲和15名父亲中存在，而按照成人治疗小组第三次报告（ATP III）标准，在8例索引患者、5名姐妹、16名母亲和11名父亲中存在。
PCOS女性的家庭成员中MS或相关代谢紊乱的发生率较高。
