Arakawa T, Satoh H, Fukuda T, Sakuma H, Nakamura H, Kobayashi K
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Digestion. 1988;41(1):1-8. doi: 10.1159/000199726.
We studied the effects of cimetidine administered intraperitoneally to rats at a dose of 20 mg/kg twice daily for 7 days on gastric mucosal integrity and endogenous prostaglandins. Cimetidine significantly (p less than 0.05) reduced the mucosal concentration of prostaglandin E2 and 6-keto-prostaglandin F1 alpha both 30 min and 24 h after the last injection of this drug, and the level had returned to normal 5 days later. Cimetidine significantly (p less than 0.01) enhanced gastric mucosal lesions induced with 0.6 N HCl 24 h after the last injection; this increased vulnerability had disappeared 5 days later. Cimetidine did not affect the synthesis of these prostanoids in isolated gastric mucosa in vitro. Gastric secretion, which was significantly (p less than 0.05) inhibited 30 min after the last injection of cimetidine, returned to control level 24 h after the last injection. The increase in gastric mucosal vulnerability observed 24 h after the last cimetidine injection might be related to a decrease in the prostanoid content and recovery of acid secretion.
我们研究了以20毫克/千克的剂量每日两次腹腔注射西咪替丁，持续7天，对大鼠胃黏膜完整性和内源性前列腺素的影响。在最后一次注射该药物30分钟和24小时后，西咪替丁均显著（p小于0.05）降低了前列腺素E2和6-酮-前列腺素F1α的黏膜浓度，且该水平在5天后恢复正常。在最后一次注射24小时后，西咪替丁显著（p小于0.01）增强了由0.6N盐酸诱导的胃黏膜损伤；这种增加的易损性在5天后消失。西咪替丁在体外不影响分离的胃黏膜中这些前列腺素的合成。在最后一次注射西咪替丁30分钟后，胃分泌受到显著（p小于0.05）抑制，在最后一次注射24小时后恢复到对照水平。在最后一次注射西咪替丁24小时后观察到的胃黏膜易损性增加可能与前列腺素含量的降低和胃酸分泌的恢复有关。
