Arakawa T, Nakamura H, Chono S, Satoh H, Yamada H, Ono T, Kobayashi K
Tohoku J Exp Med. 1983 Aug;140(4):407-12. doi: 10.1620/tjem.140.407.
The effects of cimetidine and gefarnate on endogenous prostacyclin, prostaglandin E2 and thromboxane were studied in vivo in rat gastric mucosa. The animals received cimetidine (20 mg/kg, i.p.) and/or gefarnate (100 mg/kg, s.c.) twice a day for 7 days. Gastric mucosal 6-keto-prostaglandin F1 alpha (as prostacyclin), prostaglandin E2 and thromboxane B2 (as thromboxane A2) were determined by radioimmunoassay. Cimetidine reduced prostacyclin, prostaglandin E2, but not thromboxane A2. Gefarnate inhibited the cimetidine-induced reduction of prostacyclin and prostaglandin E2; in cimetidine-untreated controls, it did not produce an increase in those prostaglandins and thromboxane A2 above the normal levels.
在大鼠胃黏膜中对西咪替丁和吉法酯对内源性前列环素、前列腺素E2和血栓素的影响进行了体内研究。动物每天两次接受西咪替丁（20mg/kg，腹腔注射）和/或吉法酯（100mg/kg，皮下注射），持续7天。通过放射免疫分析法测定胃黏膜6-酮-前列腺素F1α（作为前列环素）、前列腺素E2和血栓素B2（作为血栓素A2）。西咪替丁降低了前列环素、前列腺素E2，但未降低血栓素A2。吉法酯抑制了西咪替丁诱导的前列环素和前列腺素E2的降低；在未用西咪替丁治疗的对照组中，它并未使这些前列腺素和血栓素A2高于正常水平。
