西咪替丁和法莫替丁对大鼠胃黏膜内源性前列环素、前列腺素E2和血栓素作用方式的差异。

Difference in mode of action of cimetidine and gefarnate on endogenous prostacyclin, prostaglandin E2 and thromboxane in rat gastric mucosa.

作者信息

Arakawa T, Nakamura H, Chono S, Satoh H, Yamada H, Ono T, Kobayashi K

出版信息

Tohoku J Exp Med. 1983 Aug;140(4):407-12. doi: 10.1620/tjem.140.407.

DOI:10.1620/tjem.140.407

Abstract

The effects of cimetidine and gefarnate on endogenous prostacyclin, prostaglandin E2 and thromboxane were studied in vivo in rat gastric mucosa. The animals received cimetidine (20 mg/kg, i.p.) and/or gefarnate (100 mg/kg, s.c.) twice a day for 7 days. Gastric mucosal 6-keto-prostaglandin F1 alpha (as prostacyclin), prostaglandin E2 and thromboxane B2 (as thromboxane A2) were determined by radioimmunoassay. Cimetidine reduced prostacyclin, prostaglandin E2, but not thromboxane A2. Gefarnate inhibited the cimetidine-induced reduction of prostacyclin and prostaglandin E2; in cimetidine-untreated controls, it did not produce an increase in those prostaglandins and thromboxane A2 above the normal levels.

摘要

在大鼠胃黏膜中对西咪替丁和吉法酯对内源性前列环素、前列腺素E2和血栓素的影响进行了体内研究。动物每天两次接受西咪替丁（20mg/kg，腹腔注射）和/或吉法酯（100mg/kg，皮下注射），持续7天。通过放射免疫分析法测定胃黏膜6-酮-前列腺素F1α（作为前列环素）、前列腺素E2和血栓素B2（作为血栓素A2）。西咪替丁降低了前列环素、前列腺素E2，但未降低血栓素A2。吉法酯抑制了西咪替丁诱导的前列环素和前列腺素E2的降低；在未用西咪替丁治疗的对照组中，它并未使这些前列腺素和血栓素A2高于正常水平。