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新生儿期颅内出血所致神经后遗症的骨髓单个核细胞移植结局：4例报告

Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases.

作者信息

Liem Nguyen Thanh, Huyen Truong Linh, Huong Le Thu, Doan Ngo Van, Anh Bui Viet, Anh Nguyen Thi Phuong, Tung Dang Thanh

机构信息

Cellular Manufacturing Department, Vinmec Research Institute of Stem Cell and Gene Technology, Hanoi, Vietnam.

Vinmec Times City General Hospital, Hanoi, Vietnam.

出版信息

Front Pediatr. 2020 Jan 24;7:543. doi: 10.3389/fped.2019.00543. eCollection 2019.

DOI:10.3389/fped.2019.00543
PMID:32039110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6993568/
Abstract

The aim of this study was to present primary outcomes of autologous bone marrow mononuclear cell (BMMNC) transplantation to improve neurological sequelae in four children with intracranial hemorrhage (ICH) incidence during the neonatal period. GMFM88 and modified Ashworth score were used to assess motor function and muscle spasticity before BMMNC transplantation and after transplantation. Brain MRI was performed to evaluate brain morphology before and after BMMNC transplantation. Bone marrow were harvested from anterior iliac crest puncture and BMMNCs were isolated using Ficoll gradient centrifugation. The microbiological testing, cell counting, and hematopoietic stem cell (hHSC CD34+ cell) analysis were performed, following which BMMNCs were infused intrathecally. Improvement in motor function was observed in all patients after transplantation. In addition, muscle spasticity was reduced in all four patients. Autologous BMMNC transplantation may improve motor function and reduce muscle spasticity in children with ICH incidence during the neonatal period.

摘要

本研究的目的是呈现自体骨髓单个核细胞（BMMNC）移植改善4例新生儿期发生颅内出血（ICH）患儿神经后遗症的主要结果。在BMMNC移植前和移植后，使用粗大运动功能测量量表88项（GMFM88）和改良Ashworth评分评估运动功能和肌肉痉挛情况。进行脑部MRI以评估BMMNC移植前后的脑形态。通过髂前上棘穿刺采集骨髓，并使用Ficoll梯度离心法分离BMMNC。进行微生物检测、细胞计数和造血干细胞（hHSC CD34+细胞）分析，随后将BMMNC鞘内注入。移植后所有患者均观察到运动功能改善。此外，所有4例患者的肌肉痉挛均减轻。自体BMMNC移植可能改善新生儿期发生ICH患儿的运动功能并减轻肌肉痉挛。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/6993568/e669339a75a2/fped-07-00543-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/6993568/0d5356e46cb7/fped-07-00543-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/6993568/e669339a75a2/fped-07-00543-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/6993568/0d5356e46cb7/fped-07-00543-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/772b/6993568/e669339a75a2/fped-07-00543-g0002.jpg

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