对于有心脏移植病史的患者，我们应该常规使用舒更葡糖来逆转神经肌肉阻滞吗？
Should we Routinely Reverse Neuromuscular Blockade with Sugammadex in Patients with a History of Heart Transplantation?
作者信息
Yuki Koichi, Scholl Rebecca
机构信息
Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Massachusetts, USA.
Department of Anesthesia, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Transl Perioper Pain Med. 2020;7(2):185-189. Epub 2020 Jan 18.
Abstract
Cases of cardiac arrest after administration of neostigmine as a neuromuscular reversal agent have been reported in the literature. Sugammadex is a new neuromuscular reversal agent that acts via a different mechanism than acetylcholinesterase inhibitors. Here we reviewed the currently available literature on the use of sugammadex and potential considerations of using sugammadex in patients with a history of heart transplantation. Based on our currently available information, sugammadex administration in heart transplant patients should warrant similar caution and preparation for cardiovascular collapse as acetylcholinesterase inhibitors.
摘要
文献中已报道了使用新斯的明作为神经肌肉阻滞剂后发生心脏骤停的病例。舒更葡糖钠是一种新型神经肌肉阻滞剂，其作用机制与乙酰胆碱酯酶抑制剂不同。在此，我们回顾了目前关于舒更葡糖钠使用的文献，以及在有心脏移植病史的患者中使用舒更葡糖钠的潜在注意事项。根据我们目前掌握的信息，在心脏移植患者中使用舒更葡糖钠时，应像使用乙酰胆碱酯酶抑制剂一样，对心血管虚脱给予同样的谨慎关注和做好相应准备。
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本文引用的文献
1
Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study.舒更葡糖与新斯的明致过敏反应发生率的比较：一项回顾性多中心观察性研究。
Br J Anaesth. 2020 Feb;124(2):154-163. doi: 10.1016/j.bja.2019.10.016. Epub 2019 Nov 30.
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Effects of Sugammadex on Time of First Postoperative Bowel Movement: A Retrospective Analysis.舒更葡糖钠对术后首次排便时间的影响：一项回顾性分析
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Sugammadex-induced bronchospasm during desflurane anaesthesia.地氟醚麻醉期间舒更葡糖钠诱发的支气管痉挛
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Sugammadex and laryngospasm.舒更葡糖钠与喉痉挛
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5
[Severe bradycardia and asystole associated with sugammadex: case report].[与舒更葡糖钠相关的严重心动过缓和心搏停止：病例报告]
Braz J Anesthesiol. 2019 Mar-Apr;69(2):218-221. doi: 10.1016/j.bjan.2018.09.010. Epub 2018 Oct 19.
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Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient: A Case Report.在一名既往健康的患者中使用舒更葡糖钠后出现严重心动过缓和心脏骤停：一例病例报告
A A Pract. 2019 Jan 1;12(1):22-24. doi: 10.1213/XAA.0000000000000834.
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Severe bradycardia and asystole after sugammadex.使用舒更葡糖钠后出现严重心动过缓和心搏停止。
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