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荷兰的先天性梅毒:病因及父母特征

Congenital syphilis in The Netherlands: cause and parental characteristics.

作者信息

Boot J M, Menke H E, van Eijk R V, Oranje A P, Stolz E

机构信息

Department of Dermatology, Rotterdam University Hospital Dijkzigt, The Netherlands.

出版信息

Genitourin Med. 1988 Oct;64(5):298-302. doi: 10.1136/sti.64.5.298.

DOI:10.1136/sti.64.5.298
PMID:3203930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1194247/
Abstract

During 1982-5 the 19S (IgM) fluorescent treponemal antibody absorption (19S (IgM) FTA-ABS) test gave positive results in 19 children. The parental histories were analysed. As five of the children were adopted, 14 pregnancies were evaluated. Mothers of foreign origin and extramarital pregnancies were found to be over-represented. Of 13 women who attended for pregnancy checkup, three were not serologically screened for syphilis. In four the infection had developed late in the course of pregnancy. In at least four treatment had not been given or had been inadequate or too late. At least two had positive 19S (IgM) FTA-ABS test results that did not indicate congenital syphilis. The possibility of false positive 19S (IgM) FTA-ABS test results is pointed out. As the male sexual partners of four of the 14 mothers had presented elsewhere with early syphilis at the time of their partner's pregnancy, adequate contact tracing appears to be important to prevent congenital syphilis in future.

摘要

在1982年至1985年期间,19S(IgM)荧光密螺旋体抗体吸收试验(19S(IgM)FTA - ABS)在19名儿童中呈阳性结果。对其父母的病史进行了分析。由于其中5名儿童是领养的,因此对14次妊娠情况进行了评估。发现有外国血统母亲和非婚妊娠的情况比例过高。在13名前来进行孕期检查的妇女中,有3名未接受梅毒血清学筛查。4名妇女在妊娠后期感染梅毒。至少有4名妇女未接受治疗,或治疗不充分或治疗过晚。至少有2名妇女19S(IgM)FTA - ABS试验结果呈阳性,但并非先天性梅毒。文中指出了19S(IgM)FTA - ABS试验结果出现假阳性的可能性。由于14名母亲中有4名的男性伴侣在其伴侣怀孕时曾在其他地方出现早期梅毒症状,因此充分的接触者追踪对于预防未来的先天性梅毒似乎很重要。

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引用本文的文献

1
Congenital syphilis in The Netherlands: diagnosis and clinical features.荷兰的先天性梅毒:诊断与临床特征
Genitourin Med. 1989 Oct;65(5):300-3. doi: 10.1136/sti.65.5.300.

本文引用的文献

1
[The 19S(IgM)-FTA-ABS test in the serodiagnosis of syphilis. Technique, sources of error and diagnostical information of results (author's transl)].[19S(IgM)-梅毒螺旋体荧光抗体吸收试验在梅毒血清学诊断中的应用。技术、误差来源及结果的诊断信息(作者译)]
Immun Infekt. 1982 Jan;10(1):23-34.
2
Erythromycin failure in the treatment of syphilis in a pregnant woman.一名孕妇梅毒治疗中红霉素治疗失败
Sex Transm Dis. 1983 Jan-Mar;10(1):36-8. doi: 10.1097/00007435-198301000-00008.
3
Inadequate treatment of syphilis in pregnancy.孕期梅毒治疗不充分。
Am J Obstet Gynecol. 1984 Dec 15;150(8):945-7. doi: 10.1016/0002-9378(84)90387-9.
4
[Neonatal syphilis despite erythromycin treatment of the mother].
Presse Med. 1984 Oct 6;13(35):2133-5.
5
Maternal and fetal infection.
Clin Obstet Gynaecol. 1974 Apr;1(1):17-39.
6
Diagnosis and therapy of patients with congenital and primary syphilis.先天性和一期梅毒患者的诊断与治疗。
Pediatr Infect Dis. 1985 Sep-Oct;4(5):602-5. doi: 10.1097/00006454-198509000-00062.