Mascola L, Pelosi R, Alexander C E
Am J Obstet Gynecol. 1984 Dec 15;150(8):945-7. doi: 10.1016/0002-9378(84)90387-9.
Pregnant women with untreated syphilis have high rates of adverse pregnancy outcome. Early syphilis in pregnancy, if not treated, results in 40% loss either by spontaneous abortions, stillbirth, or perinatal death. Another 40% of such pregnancies result in an infant born with congenital syphilis. Only 20% of such pregnancies result in a normal infant. Currently recommended treatment of early syphilis in pregnant women uses a dosage of 2.4 million U of benzathine penicillin G. Because of the potentially disastrous effect syphilis has on pregnancy outcome, the occurrence of any treatment failure must be considered seriously. In this brief report we present clinical summaries of four pregnant women treated for syphilis who represent probable treatment failures.
未治疗的梅毒孕妇出现不良妊娠结局的比例很高。孕期早期梅毒若不治疗，40%会因自然流产、死产或围产期死亡而导致妊娠失败。另外40%的此类妊娠会生出患有先天性梅毒的婴儿。只有20%的此类妊娠会生出正常婴儿。目前推荐用于治疗孕妇早期梅毒的苄星青霉素G剂量为240万单位。由于梅毒对妊娠结局有潜在的灾难性影响，任何治疗失败的情况都必须认真对待。在这份简短报告中，我们呈现了四名接受梅毒治疗的孕妇的临床总结，她们可能属于治疗失败的案例。
