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立体定向、单次 30Gy 剂量肺病变的无均整过滤器容积旋转调强治疗，治疗时间 15 分钟。

Flattening filter free VMAT for a stereotactic, single-dose of 30 Gy to lung lesion in a 15-min treatment slot.

机构信息

Department of Radiation Medicine, Medical Physics Graduate Program, University of Kentucky, Lexington, KY, USA.

出版信息

J Appl Clin Med Phys. 2020 Apr;21(4):6-12. doi: 10.1002/acm2.12829. Epub 2020 Feb 10.

DOI:10.1002/acm2.12829
PMID:32039544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7170282/
Abstract

Cone-beam CT-guided single dose of lung stereotactic body radiotherapy (SBRT) treatment with a flattening filter free (FFF) beam and volumetric modulated arc therapy (VMAT) is a safe and highly effective treatment modality for selective small lung lesions. Four-dimensional (4D) CT-based treatment plans were generated using advanced AcurosXB algorithm for heterogeneity corrections. 6X-FFF beam produced highly conformal radiosurgical dose distribution to the target and reduced lung SBRT fraction duration to less than 10 min for a single dose of 30 Gy, significantly improving patient comfort and clinic workflow. Early follow-up CT imaging results (mean, 8 months) show high local control rates (100%) with no acute lung or rib toxicity. Longer clinical follow-up in a larger patient cohort managed in this fashion is underway to further validate this treatment approach.

摘要

锥形束 CT 引导的单次肺部立体定向体部放疗（SBRT）治疗，采用平扫滤波器自由（FFF）射束和容积调强弧形治疗（VMAT），是一种安全且高效的治疗选择小的肺部病变的方法。基于四维（4D）CT 的治疗计划采用先进的 AcurosXB 算法进行不均匀性校正。6X-FFF 射束可使靶区获得高度适形的放射外科剂量分布，并将单次 30Gy 的肺部 SBRT 分割时间缩短至 10 分钟以内，显著提高了患者的舒适度和临床工作流程效率。早期的随访 CT 影像学结果（平均 8 个月）显示，局部控制率高达 100%，无急性肺或肋骨毒性。正在对这种治疗方式管理的更大患者队列进行更长时间的临床随访，以进一步验证这种治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/71571de37364/ACM2-21-6-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/8142c0a4b72f/ACM2-21-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/82c8f0610baf/ACM2-21-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/71571de37364/ACM2-21-6-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/8142c0a4b72f/ACM2-21-6-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/82c8f0610baf/ACM2-21-6-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2fb/7170282/71571de37364/ACM2-21-6-g003.jpg

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Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1077-1084. doi: 10.1016/j.ijrobp.2018.11.051. Epub 2018 Dec 1.
2
Mortality following single-fraction stereotactic body radiation therapy for central pulmonary oligometastasis.单次分割立体定向体部放射治疗中央型肺寡转移后的死亡率
J Radiosurg SBRT. 2017;4(4):325-330.
3
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Radiol Phys Technol. 2024 Mar;17(1):143-152. doi: 10.1007/s12194-023-00757-8. Epub 2023 Nov 6.
4
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5
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Radiother Oncol. 2013 Jun;107(3):414-8. doi: 10.1016/j.radonc.2013.04.016. Epub 2013 May 28.