钯催化的N-亚磺酰亚胺苯甲酰胺在室温下的脱羧邻位C(sp) -H芳基化反应
Palladium-Catalyzed Decarboxylative ortho-C(sp )-H Aroylation of N-Sulfoximine Benzamides at Room Temperature.
作者信息
Das Prasenjit, Biswas Promita, Guin Joyram
机构信息
School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata, 700032, India.
出版信息
Chem Asian J. 2020 Mar 16;15(6):920-925. doi: 10.1002/asia.201901759. Epub 2020 Feb 26.
A palladium-catalyzed method for the decarboxylative ortho C-H acylation of N-sulfoximine benzamides is developed at room temperature. The catalytic method enables easy access to various functionalized 2-aroylaromatic carboxylic acid derivatives in good isolated yields. Based on our mechanistic studies, a Pd(II)/Pd(IV) catalytic cycle that involves aroyl radical intermediate is proposed for the reaction.
开发了一种钯催化的方法，用于在室温下对N-亚磺酰亚胺苯甲酰胺进行脱羧邻位C-H酰化反应。该催化方法能够以良好的分离产率轻松获得各种官能化的2-芳酰基芳族羧酸衍生物。基于我们的机理研究，提出了一种涉及芳酰基自由基中间体的Pd(II)/Pd(IV)催化循环用于该反应。
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