Innovative Materials Research Group, Department of Textiles, Merchandising and Interiors, University of Georgia, Athens, GA, USA.
Department of Statistics, University of Georgia, Athens, GA, USA.
J Microencapsul. 2020 May;37(3):205-219. doi: 10.1080/02652048.2020.1720029. Epub 2020 Feb 17.
Retinyl palmitate was encapsulated in wax matrix by melt dispersion for the purpose of economic and sustainable cosmeceutical formulation with minimum use of synthetic chemicals. We evaluated the effect of different process variables of microencapsulation by melt dispersion. In this study, a three level definitive screening design was applied, where the microcapsule properties were analysed through statistical analysis to understand the effect of four process variables: type of wax, theoretical loading capacity, surface concentration and stirring speed. Microparticles were characterised for size using image analysis; loading capacity and encapsulation efficiency using ultraviolet-visible spectroscopy; antioxidant activity through DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Melt dispersion method was effective to produce microcapsules with a spherical shape and mean size as small as 28 µm. The encapsulation efficiency ranged 60-80%. Theoretical loading capacity (-value = 0.00232, significance level, = 1%) and surfactant% ( = 0.0573, = 10%) were found to be the most significant factors to control the actual loading capacity and size of microcapsules.
棕榈酸视黄酯通过熔融分散法被包封在蜡基质中，目的是经济且可持续地制备化妆品制剂，同时最小化使用合成化学品。我们评估了熔融分散法微囊化的不同工艺变量的效果。在这项研究中，应用了三水平析因设计，通过统计分析来分析微胶囊特性，以了解四个工艺变量（蜡的类型、理论载药量、表面浓度和搅拌速度）的影响。使用图像分析对粒径进行特征分析；使用紫外可见光谱法测定载药量和包封效率；通过 DPPH（2,2-二苯基-1-苦基肼）测定法测定抗氧化活性。熔融分散法可有效制备粒径小至 28 µm 的球形微胶囊。包封效率在 60-80%之间。理论载药量（-值=0.00232，显著水平，=1%）和表面活性剂%（=0.0573，=10%）被发现是控制微胶囊实际载药量和粒径的最显著因素。
