Bai De, Hu Fan, Xu Huixian, Huang Jiahong, Wu Chengyu, Zhang Jiaheng, Ye Rui
Sauvage Laboratory for Smart Materials, Harbin Institute of Technology, Shenzhen 518055, China.
Inertia Shanghai Biotechnology Co., Ltd., Shanghai 200000, China.
Pharmaceutics. 2023 Feb 22;15(3):731. doi: 10.3390/pharmaceutics15030731.
Gravi-A nanoparticles, composed of retinyl propionate (RP) and hydroxypinacolone retinoate (HPR), were prepared by encapsulating the two using the high-pressure homogenization technique. The nanoparticles are effective in anti-wrinkle treatment with high stability and low irritation. We evaluated the effect of different process parameters on nanoparticle preparation. Supramolecular technology effectively produced nanoparticles with spherical shapes with an average size of 101.1 nm. The encapsulation efficiency was in the 97.98-98.35% range. The system showed a sustained release profile for reducing the irritation caused by Gravi-A nanoparticles. Furthermore, applying lipid nanoparticle encapsulation technology improved the transdermal efficiency of the nanoparticles, thereby allowing these to penetrate deep into the dermis layer to achieve precise and sustained release of active ingredients. Gravi-A nanoparticles can be extensively and conveniently used in cosmetics and other related formulations by direct application.
视黄醇丙酸酯（RP）和羟基频哪酮视黄酸酯（HPR）组成的Gravi-A纳米颗粒，是通过高压均质技术将二者包封制备而成。这些纳米颗粒在抗皱治疗中效果显著，具有高稳定性和低刺激性。我们评估了不同工艺参数对纳米颗粒制备的影响。超分子技术有效地制备出了平均尺寸为101.1 nm的球形纳米颗粒。包封率在97.98 - 98.35%范围内。该体系呈现出缓释特性，可减少Gravi-A纳米颗粒引起的刺激性。此外，应用脂质纳米颗粒包封技术提高了纳米颗粒的透皮效率，从而使其能够深入真皮层，实现活性成分的精准和持续释放。Gravi-A纳米颗粒通过直接应用可广泛且方便地用于化妆品及其他相关配方中。
