青少年和青年人群中的结直肠癌。
Colorectal Cancer in the Adolescent and Young Adult Population.
机构信息
University of Texas MD Anderson Cancer Center, Houston, TX.
University of Tennessee Health Science Center, Memphis, TN.
出版信息
JCO Oncol Pract. 2020 Jan;16(1):19-27. doi: 10.1200/JOP.19.00153.
Abstract
Colorectal cancer in the young adult population is of increasing incidence and concern. Genetic predisposition and heritable syndromes contribute to this trend, but perhaps more concerning is the majority of new diagnoses that involve no traceable genetic risk factors. Prevention and early recognition, with a high suspicion in the symptomatic young adult, are critical in attenuating recent trends. Clinical management requires coordinated multidisciplinary care from diagnosis to surveillance in order to ensure appropriate management. This review provides a summary of key aspects related to colorectal cancer in adolescents and young adults, including epidemiology, biology, genetics, clinical management, and prevention.
摘要
青年人群中的结直肠癌发病率和关注度日益增加。遗传易感性和遗传性综合征是导致这一趋势的原因之一，但更令人担忧的是，大多数新诊断病例并没有可追溯的遗传风险因素。在有症状的青年人群中，预防和早期发现至关重要，可以减缓这一趋势。从诊断到监测，临床管理需要多学科的协调护理，以确保进行适当的管理。本综述总结了与青少年和青年人群中的结直肠癌相关的关键方面，包括流行病学、生物学、遗传学、临床管理和预防。
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