Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Systems Neuroscience Center, Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, United States.
Elife. 2020 Feb 10;9:e53038. doi: 10.7554/eLife.53038.
The production of action sequences is a fundamental aspect of motor skills. To examine whether primary motor cortex (M1) is involved in maintenance of sequential movements, we trained two monkeys () to perform two sequential reaching tasks. In one task, sequential movements were instructed by visual cues, whereas in the other task, movements were generated from memory after extended practice. After the monkey became proficient with performing the tasks, we injected an inhibitor of protein synthesis, anisomycin, into M1 to disrupt information storage in this area. Injection of anisomycin in M1 had a marked effect on the performance of sequential movements that were guided by memory. In contrast, the anisomycin injection did not have a significant effect on the performance of movements guided by vision. These results suggest that M1 of non-human primates is involved in the maintenance of skilled sequential movements.
动作序列的产生是运动技能的一个基本方面。为了研究初级运动皮层（M1）是否参与了序列运动的维持，我们训练了两只猴子（）来执行两个序列的伸手任务。在一个任务中，序列运动由视觉线索来指导，而在另一个任务中，在经过长时间的练习后，运动是从记忆中产生的。当猴子熟练地完成任务后，我们将一种蛋白质合成抑制剂——放线菌酮注入 M1 以破坏该区域的信息存储。M1 中的放线菌酮注射对由记忆指导的序列运动的表现有显著影响。相比之下，放线菌酮注射对由视觉指导的运动表现没有显著影响。这些结果表明，非人类灵长类动物的 M1 参与了熟练的序列运动的维持。
