• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Choline as a prevention for Alzheimer's disease.

作者信息

Velazquez Ramon, Winslow Wendy, Mifflin Marc A

机构信息

Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.

出版信息

Aging (Albany NY). 2020 Feb 9;12(3):2026-2027. doi: 10.18632/aging.102849.

DOI:10.18632/aging.102849
PMID:32039834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7041773/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f7/7041773/0c09ffa23406/aging-12-102849-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f7/7041773/0c09ffa23406/aging-12-102849-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77f7/7041773/0c09ffa23406/aging-12-102849-g001.jpg

相似文献

1
Choline as a prevention for Alzheimer's disease.胆碱作为预防阿尔茨海默病的手段。
Aging (Albany NY). 2020 Feb 9;12(3):2026-2027. doi: 10.18632/aging.102849.
2
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.围产期补充胆碱可减少淀粉样变性，并增加APPswePS1dE9阿尔茨海默病模型小鼠海马体中胆碱乙酰转移酶的表达。
PLoS One. 2017 Jan 19;12(1):e0170450. doi: 10.1371/journal.pone.0170450. eCollection 2017.
3
Human red blood cell choline uptake with age and Alzheimer's disease.人类红细胞胆碱摄取与年龄及阿尔茨海默病的关系
Neurobiol Aging. 1986 May-Jun;7(3):205-9. doi: 10.1016/0197-4580(86)90044-8.
4
Association of Tea Consumption with Risk of Alzheimer's Disease and Anti-Beta-Amyloid Effects of Tea.饮茶与阿尔茨海默病风险的关联及茶的抗β-淀粉样蛋白作用。
Nutrients. 2018 May 22;10(5):655. doi: 10.3390/nu10050655.
5
Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease.我们能否预防阿尔茨海默病？阿尔茨海默病的二级“预防”试验。
Alzheimers Dement. 2013 Mar;9(2):123-131.e1. doi: 10.1016/j.jalz.2012.12.004. Epub 2013 Feb 12.
6
Abnormal erythrocyte choline and influx in Alzheimer's disease.阿尔茨海默病中红细胞胆碱及内流异常。
Life Sci. 1986 Feb 10;38(6):485-90. doi: 10.1016/0024-3205(86)90026-3.
7
Red blood cell choline. II: Kinetics in Alzheimer's disease.红细胞胆碱。II：阿尔茨海默病中的动力学
Biol Psychiatry. 1985 Apr;20(4):375-83. doi: 10.1016/0006-3223(85)90040-x.
8
Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups.阿尔茨海默病：临床和病理亚组脑组织中的胆碱乙酰转移酶活性
Ann Neurol. 1983 Sep;14(3):284-93. doi: 10.1002/ana.410140306.
9
Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice.胆碱补充可改善 APP/PS1 转基因小鼠的行为缺陷和阿尔茨海默病样病理。
Mol Nutr Food Res. 2019 Sep;63(18):e1801407. doi: 10.1002/mnfr.201801407. Epub 2019 Jul 18.
10
Alternative therapy of Alzheimer's disease via supplementation with choline acetyltransferase.通过补充胆碱乙酰转移酶对阿尔茨海默病进行替代疗法。
Neurosci Lett. 2004 Sep 30;368(3):258-62. doi: 10.1016/j.neulet.2004.05.116.

引用本文的文献

1
Phage-Microbiota Crosstalk: Implications for Central Nervous System Disorders.噬菌体-微生物群相互作用：对中枢神经系统疾病的影响
Int J Mol Sci. 2025 Jun 26;26(13):6183. doi: 10.3390/ijms26136183.
2
A Drosophila model of prion disease and its metabolic changes in the brain.一种朊病毒病的果蝇模型及其大脑中的代谢变化。
Animal Model Exp Med. 2025 Aug;8(8):1347-1363. doi: 10.1002/ame2.70048. Epub 2025 Jul 9.
3
detection of dysregulated genes and molecular pathways in Alzheimer's disease as basis for food restoring approach.检测阿尔茨海默病中失调的基因和分子途径作为食物恢复方法的基础。

本文引用的文献

1
Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation.终身补充胆碱可通过减弱小胶质细胞激活来改善阿尔茨海默病病理及相关认知缺陷。
Aging Cell. 2019 Dec;18(6):e13037. doi: 10.1111/acel.13037. Epub 2019 Sep 27.
2
Choline Supplementation Ameliorates Behavioral Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice.胆碱补充可改善 APP/PS1 转基因小鼠的行为缺陷和阿尔茨海默病样病理。
Mol Nutr Food Res. 2019 Sep;63(18):e1801407. doi: 10.1002/mnfr.201801407. Epub 2019 Jul 18.
3
Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease.
PeerJ. 2025 Apr 7;13:e19100. doi: 10.7717/peerj.19100. eCollection 2025.
4
Gut microbiome synthesizes important core metabolites to prevent cognitive decline and mitigate onset and progression of Alzheimer's disease.肠道微生物群合成重要的核心代谢物，以预防认知能力下降，并减轻阿尔茨海默病的发病和进展。
J Alzheimers Dis Rep. 2024 Dec 23;8(1):1705-1721. doi: 10.1177/25424823241309024. eCollection 2024.
5
Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer's Disease Across Distinct Brain Regions.解析载脂蛋白 E 基因型驱动的阿尔茨海默病不同脑区的蛋白质组学和脂质组学改变。
J Proteome Res. 2024 Aug 2;23(8):2970-2985. doi: 10.1021/acs.jproteome.3c00604. Epub 2024 Jan 18.
6
A metagenomic study of gut viral markers in amyloid-positive Alzheimer's disease patients.肠道病毒标志物的宏基因组学研究在淀粉样阳性阿尔茨海默病患者中。
Alzheimers Res Ther. 2023 Aug 22;15(1):141. doi: 10.1186/s13195-023-01285-8.
7
Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review.多因素方法逆转阿尔茨海默病和 MCI 认知衰退的理由：综述。
Int J Mol Sci. 2023 Jan 14;24(2):1659. doi: 10.3390/ijms24021659.
8
A Review of Bile Acid Metabolism and Signaling in Cognitive Dysfunction-Related Diseases.胆汁酸代谢与信号在认知功能障碍相关疾病中的研究进展
Oxid Med Cell Longev. 2022 Mar 11;2022:4289383. doi: 10.1155/2022/4289383. eCollection 2022.
饮食与认知老化和阿尔茨海默病中的炎症。
Curr Nutr Rep. 2019 Jun;8(2):53-65. doi: 10.1007/s13668-019-0271-4.
4
Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations.孕期补充胆碱可通过降低多代人的脑同型半胱氨酸水平来改善阿尔茨海默病的病理状况。
Mol Psychiatry. 2020 Oct;25(10):2620-2629. doi: 10.1038/s41380-018-0322-z. Epub 2019 Jan 8.
5
Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study.孕期第三 trimester 补充胆碱可改善婴儿信息处理速度：一项随机、双盲、对照喂养研究。
FASEB J. 2018 Apr;32(4):2172-2180. doi: 10.1096/fj.201700692RR. Epub 2018 Jan 5.
6
Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.孕期补充胆碱：唐氏综合征和阿尔茨海默病的一种潜在产前治疗方法。
Curr Alzheimer Res. 2016;13(1):97-106. doi: 10.2174/1567205012666150921100311.