LP3C - EA1285, Department of Psychology, University of Western Brittany, Brest, France.
LIEN - EA4685, University of Western Brittany, Brest, France.
J Autism Dev Disord. 2020 Aug;50(8):2931-2940. doi: 10.1007/s10803-019-04361-x.
We tested endogenous pain modulation mechanisms in adults with autism spectrum disorders (ASD). Nineteen ASD adults without intellectual disabilities were included, matched with 19 healthy volunteers on the basis of sex and chronological age. An experimental pain model was used to measure excitatory and inhibitory pain mechanisms in a single session. Statistical analyses indicated that endogenous pain modulation mechanisms in ASD group did not differ significantly from those of healthy adults. The pain scores were very disparate in ASD group with a greater range of extreme scores than in control group. Unlike schizophrenic patients, there was no systematic dysfunction of endogenous excitatory pain modulation mechanisms, but the high variability requires to be wise to interpret the results and formulate conclusion.
我们测试了自闭症谱系障碍（ASD）成人的内源性疼痛调节机制。19 名无智力障碍的 ASD 成人被纳入研究，根据性别和年龄与 19 名健康志愿者相匹配。在单次疗程中使用实验性疼痛模型来测量兴奋性和抑制性疼痛机制。统计分析表明，ASD 组的内源性疼痛调节机制与健康成人没有显著差异。ASD 组的疼痛评分差异很大，极端评分的范围大于对照组。与精神分裂症患者不同，内源性兴奋性疼痛调节机制没有系统的功能障碍，但高变异性需要明智地解释结果并得出结论。
