Department of Neurology, Eastern Hospital, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610101, China.
Department of Neurology, People's Hospital of Jianyang, Jianyang 641400, China.
Aging (Albany NY). 2020 Feb 10;12(3):2647-2658. doi: 10.18632/aging.102767.
Retinoic acid (RA), produced by the metabolism of vitamin A, makes effects on depression and stroke. This study was aimed to evaluate the relationship between RA levels in serum and post-stroke depression (PSD). A single-center (Chengdu, China) prospective cohort study was conducted on patients with acute ischemic stroke. The RA serum level was measured at admission. The PSD was assessed in the 3-month follow-up. The RA-PSD relationship was evaluated with conditional logistic regression. In total, 239 ischemic stroke cases and 100 healthy controls were included. The median RA serum level in patients with ischemic stroke was 2.45 ng/ml (interquartile range [IQR], 0.72-4.33), lower(P<0.001) than 3.89 ng/ml of those in control cases ([IQR]: 2.62-5.39). The crude and adjusted odds ratios [OR] (and 95% confidence intervals [CI]) of PSD associated with an IQR increase for RA were 0.54 (0.44, 0.67) and 0.66 (0.52, 0.79), respectively. Higher ORs of PSD associated with reduced RA levels (<cut-off=2.8ng/ml) were observed (OR=3.01 [95% CI, 2.34-4.98]; P<0.001). This study revealed that, in patients with ischemic stroke, reduced RA serum level was related to higher risk of PSD at 3 months, which may be applied as a predictive indicator.
视黄酸（RA）是维生素 A 代谢产生的，对抑郁症和中风有影响。本研究旨在评估血清 RA 水平与中风后抑郁（PSD）的关系。在中国成都的一个单中心前瞻性队列研究纳入了急性缺血性中风患者。在入院时测量 RA 血清水平，在 3 个月随访时评估 PSD。采用条件逻辑回归评估 RA-PSD 关系。共纳入 239 例缺血性中风病例和 100 例健康对照。中风患者的 RA 血清中位数为 2.45ng/ml（四分位距 [IQR]，0.72-4.33），低于对照组的 3.89ng/ml（IQR：2.62-5.39，P<0.001）。RA 每增加一个 IQR，与 PSD 相关的未校正和校正比值比[OR]（和 95%置信区间[CI]）分别为 0.54（0.44，0.67）和 0.66（0.52，0.79）。RA 水平降低（<cut-off=2.8ng/ml）与 PSD 风险升高的相关性更强（OR=3.01[95%CI，2.34-4.98]；P<0.001）。本研究表明，在缺血性中风患者中，血清 RA 水平降低与 3 个月时 PSD 风险升高相关，可作为预测指标。
