Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Int J Mol Sci. 2020 Feb 6;21(3):1071. doi: 10.3390/ijms21031071.
Rheumatoid arthritis (RA) is one of the inflammatory joint diseases that display features of articular cartilage destruction. The underlying disturbance results from immune dysregulation that directly and indirectly influence chondrocyte physiology. In the last years, significant evidence inferred from studies in vitro and in the animal model offered a more holistic vision of chondrocytes in RA. Chondrocytes, despite being one of injured cells in RA, also undergo molecular alterations to actively participate in inflammation and matrix destruction in the human rheumatoid joint. This review covers current knowledge about the specific cellular and biochemical mechanisms that account for the chondrocyte signatures of RA and its potential applications for diagnosis and prognosis in RA.
类风湿关节炎（RA）是一种炎症性关节疾病，表现为关节软骨破坏的特征。其根本紊乱是由免疫失调引起的，这种免疫失调直接和间接影响软骨细胞的生理功能。在过去几年中，体外研究和动物模型的大量证据为 RA 中的软骨细胞提供了更全面的认识。尽管软骨细胞是 RA 中受损的细胞之一，但它们也会发生分子改变，从而积极参与人类类风湿关节的炎症和基质破坏。这篇综述涵盖了目前关于导致 RA 中软骨细胞特征的特定细胞和生化机制的知识，以及它们在 RA 的诊断和预后中的潜在应用。
