帕金森病患者与健康个体钙相关因子的比较。

Comparison of the calcium-related factors in Parkinson's disease patients with healthy individuals.

作者信息

Samavarchi Tehrani Sadra, Sarfi Mohammad, Yousefi Tooba, Ahmadi Ahangar Alijan, Gholinia Hemmat, Mohseni Ahangar Reza, Maniati Mahmoud, Saadat Payam

机构信息

Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Caspian J Intern Med. 2020 Winter;11(1):28-33. doi: 10.22088/cjim.11.1.28.

DOI:10.22088/cjim.11.1.28

PMID:32042383

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6992725/

Abstract

BACKGROUND

Parkinson's disease (PD) is one of the most common neurodegenerative diseases (ND). Studies have demonstrated that biochemical markers have an association with PD. We aimed to investigate an association of biochemical markers including calcium, vitamin D, alkaline phosphatase (ALP), parathormone (PTH), and phosphorous with PD.

METHODS

This study was conducted on 139 PD patients and 100 healthy individuals. Serum levels of calcium, phosphorous, ALP, PTH and vitamin D were evaluated. Furthermore, student's t-test and logistic regression models were used by SPSS.

RESULTS

The mean levels of calcium (9.4±0.7 and 9.0±0.8 ) and vitamin D (29.7±22.1 and 25.8±23.7) were higher in PD patients as compared with healthy controls, which only status of calcium being significantly different in the two groups (P<0.001). Levels of ALP (202.4±96.7 and 242.9±142.4) and phosphorous (3.6±0.6 and 4.22±1.1) were significantly different comparing PD patients with healthy subjects (P<0.01, P<0.001, respectively). ALP and phosphorous were significantly different in the two groups (OR=0.996, [CI 95%, 0.994-0.999], P<0.001, OR=0.475, [CI 95%, 0.325-0.694], P<0.001, respectively). Furthermore, increased levels of calcium resulted in an elevated risk of PD (OR=2.175, [CI 95% 1.377-3.435], P<0.001).

CONCLUSION

Results show that mean levels of calcium are higher in PD patients relative to healthy controls. Thereby, higher levels of calcium may be associated with PD.

摘要

背景

帕金森病（PD）是最常见的神经退行性疾病（ND）之一。研究表明，生化标志物与帕金森病有关。我们旨在研究包括钙、维生素D、碱性磷酸酶（ALP）、甲状旁腺激素（PTH）和磷在内的生化标志物与帕金森病之间的关联。

方法

本研究对139例帕金森病患者和100名健康个体进行。评估血清钙、磷、ALP、PTH和维生素D水平。此外，使用SPSS进行学生t检验和逻辑回归模型分析。

结果

与健康对照组相比，帕金森病患者的钙（9.4±0.7和9.0±0.8）和维生素D（29.7±22.1和25.8±23.7）平均水平较高，两组间仅钙水平存在显著差异（P<0.001）。帕金森病患者与健康受试者相比，ALP（202.4±96.7和242.9±142.4）和磷（3.6±0.6和4.22±1.1）水平存在显著差异（分别为P<0.01，P<0.001）。两组间ALP和磷存在显著差异（OR=0.996，[95%CI，0.994 - 0.999]，P<0.001，OR=0.475，[95%CI，0.325 - 0.694]，P<0.001）。此外，钙水平升高导致帕金森病风险增加（OR=2.175，[95%CI 1.377 - 3.435]，P<0.001）。