Bracha Marietta, Jaroch Alina, Wojtasik Jakub
Department of Geriatrics, Division of Biochemistry and Biogerontology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85626, Poland, Bydgoszcz.
Centre for Statistical Analysis Nicolaus Copernicus University in Torun, 87100, Toruń, Poland.
Obes Surg. 2025 Feb;35(2):434-440. doi: 10.1007/s11695-024-07637-z. Epub 2025 Jan 15.
Bariatric surgeries, such as laparoscopic sleeve gastrectomy (LSG), not only result in significant weight loss but also improve the inflammatory state in obese patients. This study aimed to investigate the effects of LSG on weight loss and inflammation status in bariatric patients 1-year post-procedure.
This prospective cohort study was conducted from September 2022 to May 2024. Fifty obese adults were enrolled for LSG. All patients underwent assessments of body measurements, as well as levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) at baseline, and then at 3 and 12 months post-surgery.
Twelve months post-surgery, body measurements showed a significant reduction, with a median excess weight loss (%EWL) of 56.8%, indicating the clinical success of the bariatric procedure. %EWL showed a strong correlation with waist circumference (R = - 0.738, p < 0.00001). A logistic regression model indicated that a reduction of just 1 cm in initial waist circumference increases the likelihood of a positive outcome in laparoscopic sleeve gastrectomy by 12%. Moreover, a significant increase was observed for IL-10 (p < 0.0001), simultaneously with a significant decrease in IL-6 (p < 0.0001).
This study provides valuable evidence supporting the benefits of laparoscopic sleeve gastrectomy for both weight loss and reducing inflammation. Waist circumference emerged as a strong predictor of metabolic success 1-year post-surgery, while increased IL-10 levels signaled positive immunological changes.
减肥手术，如腹腔镜袖状胃切除术（LSG），不仅能显著减轻体重，还能改善肥胖患者的炎症状态。本研究旨在调查LSG对减肥患者术后1年体重减轻和炎症状态的影响。
本前瞻性队列研究于2022年9月至2024年5月进行。50名肥胖成年人接受了LSG手术。所有患者在基线时以及术后3个月和12个月时接受了身体测量以及白细胞介素-6（IL-6）和白细胞介素-10（IL-10）水平的评估。
术后12个月，身体测量结果显示显著下降，中位超重减轻率（%EWL）为56.8%，表明减肥手术取得了临床成功。%EWL与腰围呈强相关性（R = -0.738，p < 0.00001）。逻辑回归模型表明，初始腰围仅减少1厘米，腹腔镜袖状胃切除术取得阳性结果的可能性就增加12%。此外，观察到IL-10显著增加（p < 0.0001），同时IL-6显著下降（p < 0.0001）。
本研究提供了有价值的证据，支持腹腔镜袖状胃切除术在减肥和减轻炎症方面的益处。腰围成为术后1年代谢成功的有力预测指标，而IL-10水平升高表明免疫发生了积极变化。
