Blomaard L C, Lucke J A, de Gelder J, Anten S, Alsma J, Schuit S C E, Gussekloo J, de Groot B, Mooijaart S P
Departments of 1Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands.
Neth J Med. 2020 Feb;78(1):25-33.
Acutely hospitalised older patients with indications related to internal medicine have high risks of adverse outcomes. We investigated whether risk stratification using the Acutely Presenting Older Patient (APOP) screening tool associates with clinical outcomes in this patient group.
Patients aged ≥ 70 years who visited the Emergency Department (ED) and were acutely hospitalised for internal medicine were followed prospectively. The APOP screener assesses demographics, physical and cognitive function at ED presentation, and predicts 3-month mortality and functional decline in the older ED population. Patients with a predicted risk ≥ 45% were considered 'high risk'. Clinical outcome was hospital length of stay (LOS), and adverse outcomes were mortality and functional decline, 3 and 12 months after hospitalisation.
We included 319 patients, with a median age of 80 (IQR 74-85) years, of whom 94 (29.5%) were categorised as 'high risk' by the APOP screener. These patients had a longer hospital LOS compared to 'low risk' patients 5 (IQR 3-10) vs. 3 (IQR 1-7) days, respectively; p = 0.006). At 3 months, adverse outcomes were more frequent in 'high risk' patients compared to 'low risk' patients (59.6% vs. 34.7%, respectively; p < 0.001). At 12 months, adverse outcomes (67.0% vs. 46.2%, respectively; p = 0.001) and mortality (48.9% vs. 28.0%, respectively; p < 0.001) were greater in 'high risk' compared to 'low risk' patients.
The APOP screener identifies acutely hospitalised internal medicine patients at high risk for poor short and long-term outcomes. Early risk stratification at admission could aid in individualised treatment decisions to optimise outcomes for older patients.
因内科相关指征而急性住院的老年患者发生不良结局的风险较高。我们调查了使用急性就诊老年患者(APOP)筛查工具进行风险分层是否与该患者群体的临床结局相关。
对年龄≥70岁、前往急诊科(ED)并因内科疾病急性住院的患者进行前瞻性随访。APOP筛查工具评估患者就诊急诊科时的人口统计学、身体和认知功能,并预测老年急诊科患者3个月的死亡率和功能衰退情况。预测风险≥45%的患者被视为“高风险”。临床结局为住院时间(LOS),不良结局为住院后3个月和12个月时的死亡率和功能衰退。
我们纳入了319例患者,中位年龄为80岁(四分位间距74 - 85岁),其中94例(29.5%)被APOP筛查工具归类为“高风险”。与“低风险”患者相比,这些患者的住院时间更长,分别为5天(四分位间距3 - 10天)和3天(四分位间距1 - 7天);p = 0.006)。在3个月时,“高风险”患者的不良结局比“低风险”患者更频繁(分别为59.6%和34.7%;p < 0.001)。在12个月时,“高风险”患者的不良结局(分别为67.0%和46.2%;p = 0.001)和死亡率(分别为48.9%和28.0%;p < 0.001)均高于“低风险”患者。
APOP筛查工具可识别出急性住院内科患者短期和长期结局不佳的高风险患者。入院时的早期风险分层有助于做出个体化治疗决策,以优化老年患者的结局。