Division of Neonatal-Perinatal Medicine, UT Southwestern Medical Center at Dallas, TX, USA.
Department of Newborn Care, The Royal Hospital for Women, Randwick, NSW, Australia; School of Women's and Children's Health, University of New South Wales, Randwick, NSW, Australia.
Semin Fetal Neonatal Med. 2020 Apr;25(2):101081. doi: 10.1016/j.siny.2020.101081. Epub 2020 Jan 16.
Premature infants undergo a complex postnatal adaptation at birth. For last two centuries, oxygen has been integral to respiratory support of preterm infants at birth. Excess oxygen can cause oxidative stress and tissue injury. Preterm infants due to lung immaturity may need oxygen for successful transition at birth. Although, considerable progress has been made in the last 3 decades, optimum oxygen therapy for preterm delivery room resuscitation remains unknown. In this review, we discuss the history and physiology behind oxygen therapy in the delivery room, evaluate current literature, provide practice points and point out knowledge gaps of oxygen therapy in preterm infant at birth.
早产儿在出生后会经历复杂的后天适应过程。在过去的两个世纪中，氧气一直是早产儿出生时呼吸支持的重要组成部分。过多的氧气会导致氧化应激和组织损伤。由于肺部不成熟，早产儿可能需要氧气才能在出生时成功过渡。尽管在过去的 30 年中已经取得了相当大的进展，但最佳的早产儿分娩室复苏氧疗仍不清楚。在这篇综述中，我们讨论了分娩室氧疗背后的历史和生理学，评估了当前的文献，提供了实践要点，并指出了早产儿出生时氧疗的知识空白。
