Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, 78350 Jouy-en-Josas, France.
Biochim Biophys Acta Gene Regul Mech. 2020 May;1863(5):194502. doi: 10.1016/j.bbagrm.2020.194502. Epub 2020 Feb 7.
Bacteria are sophisticated systems with high capacity and flexibility to adapt to various environmental conditions. Each prokaryote however possesses a defined metabolic network, which sets its overall metabolic capacity, and therefore the maximal growth rate that can be reached. To achieve optimal growth, bacteria adopt various molecular strategies to optimally adjust gene expression and optimize resource allocation according to the nutrient availability. The resulting physiological changes are often accompanied by changes in the growth rate, and by global regulation of gene expression. The growth-rate-dependent variation of the abundances in the cellular machineries, together with condition-specific regulatory mechanisms, affect RNA metabolism and fate and pose a challenge for rational gene expression reengineering of synthetic circuits. This article is part of a Special Issue entitled: RNA and gene control in bacteria, edited by Dr. M. Guillier and F. Repoila.
细菌是具有高度能力和灵活性的复杂系统，能够适应各种环境条件。然而，每个原核生物都拥有一个定义明确的代谢网络，该网络设定了其整体代谢能力，因此也设定了可以达到的最大生长速率。为了实现最佳生长，细菌采用各种分子策略根据营养物质的可用性来最佳地调整基因表达并优化资源分配。由此产生的生理变化通常伴随着生长速率的变化和基因表达的全局调控。细胞机器丰度的生长速率依赖性变化，以及特定于条件的调控机制，会影响 RNA 代谢和命运，并对合成回路的合理基因表达再工程提出挑战。本文是由 M. Guillier 和 F. Repoila 博士编辑的题为“细菌中的 RNA 和基因控制”的特刊的一部分。
