From the Department of Anesthesiology and Pain Medicine, and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada (F.W.A.) the Department of Anesthesia (F.W.A., D.N.W., R.B., A.M., V.W.S.C.) the Institute of Health Policy, Management, and Evaluation (D.N.W., A.L.) the Department of Medicine (A.L.) the Dalla Lana School of Public Health (K.E.T.), University of Toronto, Toronto, Canada the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Canada (F.W.A., D.N.W., A.L.) the Department of Anesthesia (D.N.W.) the Department of Medicine (A.L.), St. Michael's Hospital, Toronto, Canada the Department of Anesthesia and Pain Management, University Health Network, Toronto, Canada (D.N.W., V.W.S.C.) the Department of Anesthesia, Women's College Hospital, Toronto, Canada (R.B.) the Department of Anesthesia, North York General Hospital, Toronto, Canada (A.M.) the Department of Anesthesia, Wexner Medical Center, Ohio State University, Columbus, Ohio (N.H.) the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada (K.E.T.).
Anesthesiology. 2020 Apr;132(4):839-853. doi: 10.1097/ALN.0000000000003132.
Interscalene brachial plexus block, the pain relief standard for shoulder surgery, is an invasive technique associated with important complications. The subomohyoid anterior suprascapular block is a potential alternative, but evidence of its comparative analgesic effect is sparse. The authors tested the hypothesis that anterior suprascapular block is noninferior to interscalene block for improving pain control after shoulder surgery. As a secondary objective, the authors evaluated the success of superior trunk (C5-C6 dermatomes) block with suprascapular block.
In this multicenter double-blind noninferiority randomized trial, 140 patients undergoing shoulder surgery were randomized to either interscalene or anterior suprascapular block with 15 ml of ropivacaine 0.5% and epinephrine. The primary outcome was area under the curve of postoperative visual analog scale pain scores during the first 24 h postoperatively. The 90% CI for the difference (interscalene-suprascapular) was compared against a -4.4-U noninferiority margin. Secondary outcomes included presence of superior trunk blockade, pain scores at individual time points, opioid consumption, time to first analgesic request, opioid-related side-effects, and quality of recovery.
A total of 136 patients were included in the analysis. The mean difference (90% CI) in area under the curve of pain scores for the (interscalene-suprascapular) comparison was -0.3 U (-0.8 to 0.12), exceeding the noninferiority margin of -4.4 U and demonstrating noninferiority of suprascapular block. The risk ratio (95% CI) of combined superior trunk (C5-C6 dermatomes) blockade was 0.98 (0.92 to 1.01), excluding any meaningful difference in superior trunk block success rates between the two groups. When differences in other analgesic outcomes existed, they were not clinically important.
The suprascapular block was noninferior to interscalene block with respect to improvement of postoperative pain control, and also for blockade of the superior trunk. These findings suggest that the suprascapular block consistently blocks the superior trunk and qualify it as an effective interscalene block alternative.
经锁骨上臂丛神经阻滞是肩部手术的止痛标准,但其为一种有创技术,相关并发症也很重要。肩胛上神经前锁骨头阻滞是一种潜在的替代方法,但关于其比较镇痛效果的证据很少。作者检验了肩胛上神经阻滞与经锁骨上臂丛神经阻滞相比改善肩部手术后疼痛控制的非劣效性假设。作为次要目标,作者评估了肩胛上神经阻滞联合上干(C5-C6 皮节)阻滞的成功率。
在这项多中心、双盲、非劣效性随机试验中,140 例接受肩部手术的患者被随机分为经锁骨上臂丛神经阻滞组或肩胛上神经阻滞组,每组接受 15ml 0.5%罗哌卡因和肾上腺素。主要结局是术后 24 小时内术后视觉模拟评分曲线下面积。比较 90%置信区间(CI)的差异(经锁骨上-肩胛上)与 -4.4U 的非劣效性边界。次要结局包括上干阻滞的存在、各个时间点的疼痛评分、阿片类药物的消耗量、首次镇痛请求的时间、阿片类药物相关的副作用以及恢复质量。
共 136 例患者纳入分析。疼痛评分曲线下面积的(经锁骨上-肩胛上)比较的平均差值(90%CI)为 -0.3U(-0.8 至 0.12),超过了 -4.4U 的非劣效性边界,表明肩胛上神经阻滞具有非劣效性。联合上干(C5-C6 皮节)阻滞的风险比(95%CI)为 0.98(0.92 至 1.01),排除了两组之间在上干阻滞成功率方面的任何有意义的差异。当存在其他镇痛结局差异时,这些差异并不具有临床意义。
肩胛上神经阻滞在改善术后疼痛控制方面与经锁骨上臂丛神经阻滞同样有效,而且也能阻滞上干。这些发现表明肩胛上神经阻滞始终能阻滞上干,这使其成为经锁骨上臂丛神经阻滞的有效替代方法。