Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
U.S. Agency for International Development, Kenya/East Africa Regional Mission, Nairobi, Kenya.
AIDS. 2020 May 1;34(6):923-930. doi: 10.1097/QAD.0000000000002500.
The aim of this study was to evaluate HIV testing yield under several candidate strategies for outreach testing at venues (i.e. places where people socialize and meet new sex partners) in East Africa cross-border areas.
Population-based cross-sectional biobehavioural survey of people who had not been previously diagnosed with HIV found in venues.
We identified participants who would have been tested for HIV under each of 10 hypothetical outreach testing strategies and calculated the proportion who would have newly tested positive for HIV under each strategy. On the basis of this proportion, we calculated the 'number needed to test' (NNT) to identify one new case of HIV under each strategy. All estimates were obtained by applying survey sampling weights to account for the complex sampling design.
If testing was performed at a random sample of venues, 35 people would need to be tested to identify one new case of HIV, but higher yield could be found by limiting testing to venues with specific characteristics. Strategies focusing on women had higher testing yield. Testing women employed by venues would result in highest yield of all strategies examined (NNT = 15), while testing men under age 24 would result in the lowest yield (NNT = 99).
Quantitatively evaluating HIV testing strategies prior to implementation using survey data presents a new opportunity to refine and prioritize outreach testing strategies for the people and places most likely to result in high HIV testing yield.
本研究旨在评估东非跨境地区场所有关外联检测的几种候选策略下的 HIV 检测效果。
在场所中对以前未被诊断出 HIV 的人群进行基于人群的横断面生物行为调查。
我们确定了在 10 种假设的外联检测策略下每个人都将接受 HIV 检测的参与者,并计算了每种策略下新发现 HIV 阳性的比例。在此基础上,我们计算了每种策略下识别一个新 HIV 病例所需的“检测次数”(NNT)。所有估计值均通过应用调查抽样权重来考虑复杂的抽样设计。
如果在随机选择的场所进行检测,则需要检测 35 人才能发现一例新的 HIV 病例,但通过将检测限于具有特定特征的场所,可以获得更高的检测效果。针对女性的策略具有更高的检测效果。对场所雇用的女性进行检测将产生所有检测策略中最高的检测效果(NNT=15),而对 24 岁以下男性进行检测则产生最低的检测效果(NNT=99)。
使用调查数据在实施前定量评估 HIV 检测策略为最有可能导致高 HIV 检测效果的人群和场所提供了优化和优先考虑外联检测策略的新机会。