Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
U.S. Agency for International Development, Kenya/East Africa Regional Mission, Nairobi, Kenya.
J Int AIDS Soc. 2019 Jan;22(1):e25226. doi: 10.1002/jia2.25226.
HIV care and treatment in cross-border areas in East Africa face challenges perhaps not seen to the same extent in other geographic areas, particularly for mobile and migrant populations. Here, we estimate the proportion of people with HIV found in these cross-border areas in each stage of the HIV care and treatment cascade, including the proportion who knows their status, the proportion on treatment and the proportion virally suppressed.
Participants (n = 11,410) working or socializing in public places in selected East Africa cross border areas were recruited between June 2016 and February 2017 using the Priorities for Local AIDS Control Efforts method and administered a behavioural survey and rapid HIV test. This approach was designed to recruit a stratified random sample of people found in public spaces or venues in each cross border area. For participants testing positive for HIV, viral load was measured from dried blood spots. The proportion in each step of the cascade was estimated using inverse probability weights to account for the sampling design and informative HIV test refusals. Estimates are reported separately for residents of the cross border areas and non-residents found in those areas.
Overall, 43% of participants with HIV found in cross-border areas knew their status, 87% of those participants were on antiretroviral therapy (ART), and 80% of participants on ART were virally suppressed. About 20% of people with HIV found in cross border areas were sampled outside their subdistrict or subcounty of residence. While both resident and non-resident individuals who knew their status were likely to be on ART (85% and 96% respectively), people on ART recruited outside their area of residence were less likely to be suppressed (64% suppressed; 95% CI: 43, 81) compared to residents (84% suppressed; 95% CI: 75, 93).
People living in or travelling through cross-border areas may face barriers in learning their HIV status. Moreover, while non-residents were more likely to be on treatment than residents, they were less likely to be suppressed, suggesting gaps in continuity of care for people in East Africa travelling outside their area of residence despite timely initiation of treatment.
东非跨境地区的艾滋病毒护理和治疗面临着其他地理区域可能没有遇到的挑战,特别是对于流动和移民人口而言。在这里,我们估计在艾滋病毒护理和治疗级联的各个阶段在这些跨境地区发现的艾滋病毒感染者的比例,包括知晓自身状况的比例、接受治疗的比例和病毒得到抑制的比例。
2016 年 6 月至 2017 年 2 月,使用地方艾滋病控制工作重点方法在选定的东非跨境地区的公共场所工作或社交的参与者(n=11410)被招募,并进行了行为调查和快速艾滋病毒检测。这种方法旨在从每个跨境地区的公共场所或场所中招募分层随机抽样的人群。对于艾滋病毒检测呈阳性的参与者,从干血斑测量病毒载量。使用逆概率权重估计级联中的每个步骤的比例,以考虑抽样设计和信息性艾滋病毒检测拒绝。报告的估计值分别针对跨境地区的居民和在这些地区发现的非居民。
总体而言,在跨境地区发现的艾滋病毒感染者中,有 43%知晓自己的状况,其中 87%接受抗逆转录病毒治疗(ART),而接受 ART 的感染者中有 80%病毒得到抑制。在跨境地区发现的约 20%的艾滋病毒感染者是在其居住的分区或乡镇之外采样的。尽管知晓自己状况的居民和非居民都有可能接受 ART(分别为 85%和 96%),但在居住地以外地区接受治疗的感染者不太可能得到抑制(64%得到抑制;95%CI:43,81)与居民(84%得到抑制;95%CI:75,93)。
居住在或过境跨境地区的人可能在了解自身艾滋病毒状况方面面临障碍。此外,尽管非居民接受治疗的可能性高于居民,但他们得到抑制的可能性较低,这表明尽管及时开始治疗,但东非地区居民在居住地以外地区旅行的人在护理连续性方面存在差距。