Schuit K E, Krebs R E
J Reticuloendothel Soc. 1982 Jun;31(6):523-7.
The blood neutrophil response to lithium chloride challenge was determined in one-day-old and young adult rats to test the hypothesis that granulocytopoiesis is less efficient in neonates than in adults. Adult animals responded rapidly to lithium chloride treatment, showing a 134% increase in blood neutrophils on the second day of exposure and ultimately increasing by 260% by the tenth day. Newborn rats on the other hand, showed a 25% decrease in blood neutrophils after one day of treatment with lithium, then remained at that or at pretreatment levels throughout the subsequent 10 days. These observations suggest that hematopoietic tissue in the newborn is less responsive than is that of adults.
为了验证粒细胞生成在新生儿中比在成年动物中效率更低这一假设，研究人员测定了一日龄和年轻成年大鼠对氯化锂刺激的血液中性粒细胞反应。成年动物对氯化锂治疗反应迅速，在接触的第二天血液中性粒细胞增加了134%，到第十天最终增加了260%。另一方面，新生大鼠在用锂治疗一天后血液中性粒细胞减少了25%，然后在随后的10天里一直维持在该水平或治疗前水平。这些观察结果表明，新生儿的造血组织比成年动物的造血组织反应性更低。
