Centre for Bioscience, Department of Life Sciences, Manchester Metropolitan University, Manchester, UK.
Crit Rev Microbiol. 2020 Feb;46(1):61-77. doi: 10.1080/1040841X.2020.1724872. Epub 2020 Feb 12.
Chronic kidney disease (CKD) and chronic periodontitis (CP) are both common diseases, which are found disproportionately comorbid with each other and have been reported to have a detrimental effect on the progression of each respective disease. They have an overlap in risk factors and both are a source of systemic inflammation along with a wide selection of immunological and non-specific effects that can affect the body over the lifespan of the conditions. Previous studies have investigated the directionality of the relationship between these two diseases; however, there is a lack of literature that has examined how these diseases may be interacting at the localized and systemic level. This review discusses how oral microorganisms have the ability to translocate and have distal effects and provides evidence for microbial involvement in a systemic disease. Furthermore, it summarizes the reported local and systemic effects of CKD and CP and discusses how the interaction of these effects may be responsible for directionality associations reported.
慢性肾脏病（CKD）和慢性牙周炎（CP）都是常见疾病，它们不成比例地同时存在，并被报道对各自疾病的进展都有不利影响。它们有共同的危险因素，并且都存在全身性炎症以及广泛的免疫和非特异性影响，这些影响可能会在疾病的整个生命周期中影响身体。先前的研究已经调查了这两种疾病之间关系的方向性；然而，缺乏研究这些疾病如何在局部和全身水平上相互作用的文献。这篇综述讨论了口腔微生物如何具有转移和远端作用的能力，并为微生物参与系统性疾病提供了证据。此外，它总结了 CKD 和 CP 的报道的局部和全身影响，并讨论了这些影响的相互作用如何可能导致报告的方向性关联。
