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[香菇多糖皮肤试验及OK-432在胃癌术后的免疫治疗——脾切除术的影响]

[Su-polysaccharide skin test and immunotherapy with OK-432 in postoperative gastric cancer--the effect of a splenectomy].

作者信息

Saito H, Kikkawa H, Bando H, Sakatoku M, Hirano M, Tatsuzawa T

机构信息

Dept. of Surgery, Koseiren Takaoka Hospital.

出版信息

Gan No Rinsho. 1988 Nov;34(14):1965-8.

PMID:3204664
Abstract

A SU-polysaccharide skin test (SU-PS test) has been employed and studied as a parameter for monitoring the immunological status of OK-432 treated patients who had undergone a curative gastrectomy for a gastric cancer in stages II and III. The median diameter of the erythema (SU-PS value) was found to have no relation to the number of lymphocytes and the serum protein level and was depressed by combined chemotherapy. The SU-PS value was significantly higher in patients not given a splenectomy than in patients who had undergone a patients splenectomy. The spleen is considered the essential organ to focus on in OK-432 immunotherapy.

摘要

已采用并研究了一种链球菌制剂-多糖皮肤试验(SU-PS试验),作为监测接受OK-432治疗且已接受II期和III期胃癌根治性胃切除术患者免疫状态的一个参数。发现红斑的中位直径(SU-PS值)与淋巴细胞数量和血清蛋白水平无关,且联合化疗会使其降低。未行脾切除术的患者的SU-PS值显著高于行脾切除术的患者。脾脏被认为是OK-432免疫治疗中需要重点关注的重要器官。

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