Ogawa T, Yakawa H, Ogawa K, Otani Y, Kawata H, Haga S, Kasihara T, Sakakibara N
Gan To Kagaku Ryoho. 1984 Oct;11(10):2221-6.
Immunotherapy for gastric cancer has been adopted by any institutes recently. However, immunoparameters which exactly express patients' immune status have not been determined. In this study, the Su-Ps skin test was tried to evaluate whether or not this reaction could become a usable immunoparameter. Conclusions were as follows: 1) Late-stage patients showed a significantly weak response in the Su-Ps skin test compared to early-stage patients when examined preoperatively. 2) Su-Ps skin reaction became stronger after gastrectomy in early-stage patients, while the contrary result was observed in late-stage patients. 3) Postoperative Su-Ps skin tests showed a stronger response than preoperative tests regardless of the patients' stage, when patients received OK-432 treatment. The Su-Ps skin test reaction seemed to be well-correlated with the patients' immune status as above, so that this test can be chosen for evaluation of immunotherapy.
最近，一些机构已采用免疫疗法治疗胃癌。然而，尚未确定能够准确表达患者免疫状态的免疫参数。在本研究中，尝试通过Su-Ps皮肤试验来评估该反应是否可成为可用的免疫参数。结果如下：1）术前检查时，晚期患者在Su-Ps皮肤试验中的反应明显弱于早期患者。2）早期患者胃切除术后Su-Ps皮肤反应增强，而晚期患者则出现相反结果。3）无论患者处于何阶段，接受OK-432治疗的患者术后Su-Ps皮肤试验的反应均强于术前试验。如上所述，Su-Ps皮肤试验反应似乎与患者的免疫状态密切相关，因此该试验可用于评估免疫疗法。
