Lou Hans C, Rømer Thomsen Kristine, Changeux Jean-Pierre
Center of Functionally Integrative Neuroscience, Institute for Clinical Medicine, Aarhus University, Aarhus, Denmark.
Department of Psychology and Behavioral Sciences, Center for Alcohol and Drug Research, School of Business and Social Sciences, Aarhus, Denmark.
Front Syst Neurosci. 2020 Jan 28;14:3. doi: 10.3389/fnsys.2020.00003. eCollection 2020.
The electrophysiology of the paralimbic network ("default mode") for self-awareness has drawn much attention in the past couple of decades. In contrast, knowledge of the molecular organization of conscious experience has only lately come into focus. We here review newer data on dopaminergic control of awareness in humans, particularly in self-awareness. These results implicate mainly dopaminergic neurotransmission and the control of GABAergic function directly in the paralimbic network. The findings are important for understanding addiction, developmental disorders, and dysfunctional consciousness.
在过去几十年里，用于自我意识的边缘旁网络（“默认模式”）的电生理学受到了广泛关注。相比之下，关于意识体验的分子组织的知识直到最近才成为焦点。我们在此回顾关于多巴胺能对人类意识，特别是自我意识控制的最新数据。这些结果主要表明多巴胺能神经传递以及直接对边缘旁网络中γ-氨基丁酸能功能的控制。这些发现对于理解成瘾、发育障碍和意识功能失调具有重要意义。
