Devantier Louise, Hansen Allan K, Mølby-Henriksen Jens-Jacob, Christensen Christian Bech, Lildal Tina, Pedersen Michael, Magnusson Måns, Borghammer Per, Ovesen Therese
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Department of Oto-Rhino-Laryngology, Regional Hospital West Jutland, Holsterbo, Denmark.
Front Neurol. 2020 Jan 28;11:11. doi: 10.3389/fneur.2020.00011. eCollection 2020.
The cortical metabolic activity in patients with Menière's disease has not been investigated. The aim of this study was to investigate the F-FDG cerebral uptake in Menière's patients compared to healthy controls. Eight patients with right-sided Menière's disease and fourteen healthy controls underwent a video head impulse test (vHIT), test of utricular function with ocular vestibular evoked myogenic potentials (oVEMP) and three F-FDG-based PET examinations of the brain. Participants were seated in a self-propelled chair, injected with F-FDG and then exposed to 35 min of chair motion stimulation, followed by a PET scan. Two types of natural vestibular stimuli were applied, predominantly toward the right horizontal semicircular canal (angular acceleration) and right utriculus (linear acceleration). For baseline scans, participants were injected with F-FDG while seated without movement. Analyses of baseline scans revealed decreased F-FDG-uptake in the medial part of Heschl's gyrus in the left hemisphere in patients with Menière's disease compared to healthy controls. During angular vestibular stimulation there was also a significantly decreased F-FDG uptake in the intersection between the medial part of Heschl's gyrus and the parietal operculum in the left hemisphere and bilaterally in the posterior part of insula. During linear stimulation, Menière's patients showed decreased F-FDG uptake in the medial part of Heschl's gyrus in the right hemisphere and also bilaterally in the posterior insula. In addition, decreased F-FDG uptake was seen in the thalamus during vestibular stimulation. Heschl's gyrus, the posterior part of insula, and thalamus have previously been shown to be core areas for processing vestibular inputs. Patients with Menière's disease solely differed from the healthy controls with lower cortical activity in these areas at baseline and during natural vestibular stimulation.
梅尼埃病患者的皮质代谢活动尚未得到研究。本研究的目的是调查梅尼埃病患者与健康对照者相比的F-FDG脑摄取情况。8例右侧梅尼埃病患者和14名健康对照者接受了视频头脉冲试验（vHIT）、利用眼前庭诱发肌源性电位（oVEMP）进行的椭圆囊功能测试以及三次基于F-FDG的脑部PET检查。参与者坐在自动推进椅上，注射F-FDG，然后接受35分钟的椅子运动刺激，随后进行PET扫描。应用了两种类型的自然前庭刺激，主要针对右水平半规管（角加速度）和右椭圆囊（线加速度）。对于基线扫描，参与者在坐着不动时注射F-FDG。基线扫描分析显示，与健康对照者相比，梅尼埃病患者左半球赫氏回内侧部分的F-FDG摄取减少。在角前庭刺激期间，左半球赫氏回内侧部分与顶叶岛盖交界处以及双侧岛叶后部的F-FDG摄取也显著减少。在线性刺激期间，梅尼埃病患者右半球赫氏回内侧部分以及双侧岛叶后部的F-FDG摄取减少。此外，在前庭刺激期间，丘脑的F-FDG摄取减少。赫氏回、岛叶后部和丘脑先前已被证明是处理前庭输入的核心区域。梅尼埃病患者与健康对照者的唯一不同之处在于，在基线和自然前庭刺激期间，这些区域的皮质活动较低。
