• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ⅲ期神经母细胞瘤的自发消退：一例报告。

Spontaneous regression of stage III neuroblastoma: A case report.

作者信息

Liu Jie, Wu Xiong-Wei, Hao Xi-Wei, Duan Yu-He, Wu Ling-Ling, Zhao Jing, Zhou Xian-Jun, Zhu Cheng-Zhan, Wei Bin, Dong Qian

机构信息

Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China.

Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery, Qingdao 266000, Shandong Province, China.

出版信息

World J Clin Cases. 2020 Jan 26;8(2):436-443. doi: 10.12998/wjcc.v8.i2.436.

DOI:10.12998/wjcc.v8.i2.436
PMID:32047796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7000927/
Abstract

BACKGROUND

Neuroblastoma (NB) is the most common type of extracranial solid tumour in children. The overall prognosis of NB is poor, but at the same time, NB shows significant clinical diversity. NB can demonstrate spontaneous regression or can differentiate into benign ganglioneuroma.

CASE SUMMARY

This study retrospectively analyzed the clinical data of a patient with spontaneous regression of stage III NB who was admitted in May 2015. Studies of the spontaneous regression of NB published from October 1946 to September 2019 were retrieved through PubMed. The clinical manifestations, diagnosis, treatment, and follow-up results were analysed.

CONCLUSION

Spontaneous regression of stage III NB is rare in the clinic. The report of this case is an important supplement to the study of the spontaneous regression of NB.

摘要

背景

神经母细胞瘤（NB）是儿童最常见的颅外实体瘤类型。NB的总体预后较差，但同时，NB表现出显著的临床多样性。NB可表现出自发性消退或可分化为良性神经节细胞瘤。

病例摘要

本研究回顾性分析了2015年5月收治的1例Ⅲ期NB自发消退患者的临床资料。通过PubMed检索了1946年10月至2019年9月发表的关于NB自发消退的研究。分析了临床表现、诊断、治疗及随访结果。

结论

Ⅲ期NB的自发消退在临床上较为罕见。该病例报告是NB自发消退研究的重要补充。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/9a32627819e0/WJCC-8-436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/51f3d619888f/WJCC-8-436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/58989f25bb96/WJCC-8-436-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/1bf1aea556a1/WJCC-8-436-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/9a32627819e0/WJCC-8-436-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/51f3d619888f/WJCC-8-436-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/58989f25bb96/WJCC-8-436-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/1bf1aea556a1/WJCC-8-436-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b42d/7000927/9a32627819e0/WJCC-8-436-g004.jpg

相似文献

1
Spontaneous regression of stage III neuroblastoma: A case report.Ⅲ期神经母细胞瘤的自发消退：一例报告。
World J Clin Cases. 2020 Jan 26;8(2):436-443. doi: 10.12998/wjcc.v8.i2.436.
2
Complete resection is not required in patients with neuroblastoma under 1 year of age.1岁以下的神经母细胞瘤患者无需进行完全切除。
J Pediatr Surg. 1998 Nov;33(11):1690-4. doi: 10.1016/s0022-3468(98)90611-x.
3
Results of neuroblastoma treatment in Lithuania: a single centre experience.立陶宛神经母细胞瘤治疗结果：单中心经验
Acta Med Litu. 2017;24(2):128-137. doi: 10.6001/actamedica.v24i2.3494.
4
Intracranial Metastases Tend to Be Overt and Predict Poor Prognosis in Children With Neuroblastoma.颅内转移在神经母细胞瘤患儿中往往较为明显且预示预后不良。
Front Pediatr. 2021 Nov 3;9:716880. doi: 10.3389/fped.2021.716880. eCollection 2021.
5
A comparative review of the immunobiology of murine neuroblastoma and human neuroblastoma.
Cancer. 1997 May 1;79(9):1757-66.
6
Refractory diarrhea: A paraneoplastic syndrome of neuroblastoma.难治性腹泻：神经母细胞瘤的一种副肿瘤综合征。
World J Gastroenterol. 2015 Jul 7;21(25):7929-32. doi: 10.3748/wjg.v21.i25.7929.
7
Clinical characteristics of infant neuroblastoma and a summary of treatment outcome.婴儿神经母细胞瘤的临床特征及治疗结果总结。
Oncol Lett. 2016 Dec;12(6):5356-5362. doi: 10.3892/ol.2016.5353. Epub 2016 Nov 4.
8
Outcome of [131I]metaiodobenzylguanidine therapy of neuroblastoma: seven years after.神经母细胞瘤的[131I]间碘苄胍治疗结果：七年之后
J Nucl Biol Med (1991). 1991 Oct-Dec;35(4):207-15.
9
Regression and progression in neuroblastoma. Does genetics predict tumour behaviour?神经母细胞瘤的消退与进展。遗传学能否预测肿瘤行为？
Eur J Cancer. 1995;31A(4):510-5. doi: 10.1016/0959-8049(95)00044-j.
10
Metastatic neuroblastoma with ganglioneuromatous differentiation and mandibular involvement.伴有神经节瘤样分化及下颌骨受累的转移性神经母细胞瘤。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Nov;88(5):586-92. doi: 10.1016/s1079-2104(99)70090-9.

引用本文的文献

1
The baseline F-FDG PET/CT imaging features in pediatric patients with congenital neuroblastoma.先天性神经母细胞瘤患儿的基线F-FDG PET/CT影像特征。
BMC Med Imaging. 2025 Aug 14;25(1):330. doi: 10.1186/s12880-025-01863-2.
2
Clinical value of I-metaiodobenzylguanidine single-photon emission computed tomography/computed tomography in spontaneous regression of localized congenital neuroblastoma: an evaluative study.间碘苄胍单光子发射计算机断层扫描/计算机断层扫描在局限性先天性神经母细胞瘤自发消退中的临床价值：一项评估研究
Quant Imaging Med Surg. 2025 Aug 1;15(8):6682-6691. doi: 10.21037/qims-2025-524. Epub 2025 Jul 17.
3

本文引用的文献

1
Watch and See Strategy in Selected Neuroblastoma Case Scenarios: Success and Limitations.
J Pediatr Hematol Oncol. 2019 Aug;41(6):e384-e387. doi: 10.1097/MPH.0000000000001421.
2
Defining Risk Factors for Chemotherapeutic Intervention in Infants With Stage 4S Neuroblastoma: A Report From Children's Oncology Group Study ANBL0531.定义化疗干预 4S 期神经母细胞瘤婴儿风险因素：来自儿童肿瘤学组研究 ANBL0531 的报告。
J Clin Oncol. 2019 Jan 10;37(2):115-124. doi: 10.1200/JCO.18.00419. Epub 2018 Nov 16.
3
Immune Escape Mechanisms and Future Prospects for Immunotherapy in Neuroblastoma.神经母细胞瘤的免疫逃逸机制与免疫治疗的未来前景。
Identification of genes associated with spontaneous regression of neuroblastoma.
与神经母细胞瘤自发消退相关基因的鉴定。
Pediatr Discov. 2023 Jun 9;1(1):e10. doi: 10.1002/pdi3.10. eCollection 2023 Jun.
4
Occurrence-regression-recurrence of hepatocellular carcinoma without any intervention: A case report.未经任何干预的肝细胞癌的发生-消退-复发：一例报告
Front Surg. 2022 Sep 12;9:972446. doi: 10.3389/fsurg.2022.972446. eCollection 2022.
Biomed Res Int. 2018 Feb 25;2018:1812535. doi: 10.1155/2018/1812535. eCollection 2018.
4
Neuroblastoma.神经母细胞瘤
Jpn J Clin Oncol. 2018 Mar 1;48(3):214-241. doi: 10.1093/jjco/hyx176.
5
Spontaneous regression of neuroblastoma.神经母细胞瘤的自发消退。
Cell Tissue Res. 2018 May;372(2):277-286. doi: 10.1007/s00441-017-2761-2. Epub 2018 Jan 5.
6
Stage 4S neuroblastoma tumors show a characteristic DNA methylation portrait.4S期神经母细胞瘤肿瘤呈现出特征性的DNA甲基化图谱。
Epigenetics. 2016 Oct 2;11(10):761-771. doi: 10.1080/15592294.2016.1226739.
7
Usefulness of three-dimensional(3D) simulation software in hepatectomy for pediatric hepatoblastoma.三维（3D）模拟软件在小儿肝母细胞瘤肝切除术中的应用价值
Surg Oncol. 2016 Sep;25(3):236-43. doi: 10.1016/j.suronc.2016.05.023. Epub 2016 May 20.
8
Involvement of the nuclear factor-κB signaling pathway in the regulation of CXC chemokine receptor-4 expression in neuroblastoma cells induced by tumor necrosis factor-α.核因子-κB信号通路参与肿瘤坏死因子-α诱导的神经母细胞瘤细胞中CXC趋化因子受体4表达的调控
Int J Mol Med. 2015 Feb;35(2):349-57. doi: 10.3892/ijmm.2014.2032. Epub 2014 Dec 10.
9
Neuroblastoma: molecular pathogenesis and therapy.神经母细胞瘤：分子发病机制与治疗
Annu Rev Med. 2015;66:49-63. doi: 10.1146/annurev-med-011514-023121. Epub 2014 Oct 27.
10
Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.依赖受体 UNC5D 介导神经生长因子耗竭诱导的神经母细胞瘤消退。
J Clin Invest. 2013 Jul;123(7):2935-47. doi: 10.1172/JCI65988. Epub 2013 Jun 17.