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与神经母细胞瘤自发消退相关基因的鉴定。

Identification of genes associated with spontaneous regression of neuroblastoma.

作者信息

Zhang Yunlong, Du Yifei, Wang Min, Li Changchun, Zhao Zhenzhen, Peng Liang, Zhou Jianwu, Wang Shan

机构信息

Department of Pediatric Surgical Oncology Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Pediatrics Chongqing China.

出版信息

Pediatr Discov. 2023 Jun 9;1(1):e10. doi: 10.1002/pdi3.10. eCollection 2023 Jun.

DOI:10.1002/pdi3.10
PMID:40625573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12118307/
Abstract

The study of target genes for the spontaneous regression phenomenon of neuroblastoma (NB) is still unclear. Common differentially expressed genes (DEGs) were identified by differential expression analysis in both public databases for the stage 4 death group and stage 4S survival group. The DEGs were ranked by constructing protein-protein interaction (PPI) network as well as calculating betweenness centrality (BC) values, and the relationship with NB prognosis was determined by performing univariate analysis, multifactor analysis, and lasso regression analysis on the top 10 genes and possibly correlated with spontaneous regression of NB. We identified a total of 173 DEGs, including 143 upregulated genes and 30 downregulated genes. PPI network showed a rich interaction between DEGs. We ranked the DEGs by calculating BC values and showed the top 10 genes, followed by univariate and multifactorial analyses, which showed that , , , , , , and were associated with good prognosis, and was the most closely associated with prognosis among them. By lasso regression analysis, we constructed a four-gene risk score formula. We drew a nomogram to use in clinical work and two newly identified genes associated with good prognosis in NB: and .

摘要

神经母细胞瘤（NB）自发消退现象的靶基因研究仍不明确。通过对公开数据库中4期死亡组和4S期存活组进行差异表达分析，鉴定出常见的差异表达基因（DEG）。通过构建蛋白质-蛋白质相互作用（PPI）网络以及计算介数中心性（BC）值对DEG进行排序，并通过对前10个基因进行单因素分析、多因素分析和套索回归分析来确定与NB预后的关系，这些基因可能与NB的自发消退相关。我们共鉴定出173个DEG，包括143个上调基因和30个下调基因。PPI网络显示DEG之间存在丰富的相互作用。我们通过计算BC值对DEG进行排序，并展示了前10个基因，随后进行单因素和多因素分析，结果显示， 、 、 、 、 、 以及 与良好预后相关，其中 与预后的相关性最为密切。通过套索回归分析，我们构建了一个四基因风险评分公式。我们绘制了一个列线图用于临床工作，并鉴定出两个与NB良好预后相关的新基因： 和 。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/7aef8e10d376/PDI3-1-e10-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/d5a90cf08950/PDI3-1-e10-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/b7a5c4eff61a/PDI3-1-e10-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/87aae635f858/PDI3-1-e10-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/f36cbf58896b/PDI3-1-e10-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/7aef8e10d376/PDI3-1-e10-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/d5a90cf08950/PDI3-1-e10-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/b7a5c4eff61a/PDI3-1-e10-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/87aae635f858/PDI3-1-e10-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/f36cbf58896b/PDI3-1-e10-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3772/12118307/7aef8e10d376/PDI3-1-e10-g005.jpg

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GDPD5 Related to Lipid Metabolism Is a Potential Prognostic Biomarker in Neuroblastoma.GDPD5 与脂质代谢有关，是神经母细胞瘤的一个潜在预后生物标志物。
Int J Mol Sci. 2022 Nov 8;23(22):13740. doi: 10.3390/ijms232213740.
2
Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma.单细胞景观分析揭示了原发性神经母细胞瘤中不同的消退轨迹和新的预后生物标志物。
Genes Dis. 2022 Feb 4;9(6):1624-1638. doi: 10.1016/j.gendis.2021.12.020. eCollection 2022 Nov.
3
E2F3 gene expression is a potential negative prognostic marker for localised and MYCN not-amplified neuroblastoma: Results of in silico analysis of 786 samples.
E2F3 基因表达是局部和 MYCN 非扩增神经母细胞瘤潜在的负预后标志物：786 例样本的计算机分析结果。
Pediatr Blood Cancer. 2022 Oct;69(10):e29800. doi: 10.1002/pbc.29800. Epub 2022 Jun 2.
4
A spatial interaction incorporated betweenness centrality measure.一种纳入空间相互作用的介数中心度测度。
PLoS One. 2022 May 20;17(5):e0268203. doi: 10.1371/journal.pone.0268203. eCollection 2022.
5
CNR1 may reverse progesterone-resistance of endometrial cancer through the ERK pathway.CNR1 可能通过 ERK 通路逆转子宫内膜癌的孕激素耐药性。
Biochem Biophys Res Commun. 2021 Apr 9;548:148-154. doi: 10.1016/j.bbrc.2021.02.038. Epub 2021 Feb 25.
6
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7
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8
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9
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J Biol Chem. 2017 Mar 10;292(10):4326-4335. doi: 10.1074/jbc.M117.779868. Epub 2017 Feb 6.