Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gröna Stråket 9, 413 45, Gothenburg, Sweden.
COPD Center, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Eur Arch Otorhinolaryngol. 2020 May;277(5):1353-1359. doi: 10.1007/s00405-020-05837-8. Epub 2020 Feb 11.
Chronic obstructive pulmonary disease (COPD) is associated with several co-morbidities and non-infectious rhinitis (NIR) has emerged as a new possible co-morbidity. The primary aim of this study is to confirm a previously reported association between NIR and COPD in a multicentre population over time. The secondary aim is to investigate the course over time of such an association through a comparison between early- and late-onset COPD.
This study is part of the European Community Respiratory Health Survey (ECRHS). A random adult population from 25 centres in Europe and one in Australia was examined with spirometry and answered a respiratory questionnaire in 1998-2002 (ECRHS II) and in 2008-2013 (ECRHS III). Symptoms of non-infectious rhinitis, hay fever and asthma, and smoking habits were reported. Subjects reporting asthma were excluded. COPD was defined as a spirometry ratio of FEV/FVC < 0.7. A total of 5901 subjects were included.
Non-infectious rhinitis was significantly more prevalent in subjects with COPD compared with no COPD (48.9% vs 37.1%, p < 0.001) in ECRHS II (mean age 43) but not in ECHRS III (mean age 54). In the multivariable regression model adjusted for COPD, smoking, age, BMI, and gender, non-infectious rhinitis was associated with COPD in both ECRHS II and III.
Non-infectious rhinitis was significantly more common in subjects with COPD at a mean age of 43. Ten years later, the association was weaker. The findings indicate that NIR could be associated with the early onset of COPD.
慢性阻塞性肺疾病（COPD）与多种合并症相关，非传染性鼻炎（NIR）已成为一种新的可能合并症。本研究的主要目的是在一个多中心人群中随时间确认先前报道的 NIR 与 COPD 之间的关联。次要目的是通过比较早发性和晚发性 COPD，研究这种关联随时间的变化过程。
本研究是欧洲社区呼吸健康调查（ECRHS）的一部分。来自欧洲 25 个中心和澳大利亚的一个随机成年人群接受了肺量测定和呼吸问卷检查，时间分别为 1998-2002 年（ECRHS II）和 2008-2013 年（ECRHS III）。报告了非传染性鼻炎、花粉热和哮喘的症状以及吸烟习惯。报告哮喘的受试者被排除在外。COPD 定义为 FEV/FVC 比值<0.7。共纳入 5901 名受试者。
与无 COPD 相比，在 ECRHS II（平均年龄 43 岁）中，COPD 患者的非传染性鼻炎明显更为常见（48.9%比 37.1%，p<0.001），但在 ECHRS III（平均年龄 54 岁）中则不然。在调整 COPD、吸烟、年龄、BMI 和性别后的多变量回归模型中，非传染性鼻炎与 ECRHS II 和 III 中的 COPD 相关。
在平均年龄为 43 岁的 COPD 患者中，非传染性鼻炎更为常见。10 年后，这种关联减弱。研究结果表明，NIR 可能与 COPD 的早期发病有关。
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