Department of Otorhinolaryngology, Head & Neck Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
BMC Pulm Med. 2022 Nov 9;22(1):406. doi: 10.1186/s12890-022-02203-8.
Chronic rhinosinusitis (CRS) is associated with generalised airway inflammation. Few studies have addressed the relationship between CRS and chronic bronchitis (CB).
This prospective study over a five-year period aims to investigate the risk of developing CB in subjects reporting CRS at the beginning of the study. A random sample of 7393 adult subjects from Telemark County, Norway, answered a comprehensive respiratory questionnaire in 2013 and then 5 years later in 2018. Subjects reporting CB in 2013 were excluded from the analyses. New cases of CB in 2018 were analysed in relation to having CRS in 2013 or not.
The prevalence of new-onset CB in 2018 in the group that reported CRS in 2013 was 11.8%. There was a significant increase in the odds of having CB in 2018 in subjects who reported CRS in 2013 (OR 3.8, 95% CI 2.65-5.40), adjusted for age, sex, BMI, smoking and asthma.
In this large population sample, CRS was associated with increased odds of developing CB during a five-year follow-up. Physicians should be aware of chronic bronchitis in patients with CRS.
慢性鼻-鼻窦炎（CRS）与全身性气道炎症有关。很少有研究探讨 CRS 与慢性支气管炎（CB）之间的关系。
本前瞻性研究为期五年，旨在调查在研究开始时报告患有 CRS 的受试者中发生 CB 的风险。挪威泰勒马克郡的一个随机样本，7393 名成年受试者于 2013 年回答了一份全面的呼吸问卷，然后在 2018 年再次回答。在 2013 年报告有 CB 的受试者被排除在分析之外。分析 2018 年新发生的 CB 病例与 2013 年是否患有 CRS 有关。
在 2013 年报告 CRS 的组中，2018 年新发生 CB 的患病率为 11.8%。在 2013 年报告有 CRS 的受试者中，2018 年发生 CB 的可能性显著增加（OR 3.8，95%CI 2.65-5.40），调整了年龄、性别、BMI、吸烟和哮喘因素。
在这个大型人群样本中，CRS 与五年随访期间发生 CB 的几率增加相关。医生应该意识到 CRS 患者存在慢性支气管炎。
